Androsterone and Etiocholanolone are DHEA metabolites via Androstenedione and the 5α- and 5β-reductase pathways. These androgens allow assessment of 5α-reductase activity. Normal metabolites may be a better indicator of androgen status in a patient with low DHEA and/or testosterone.
Causes of low Androsterone levels:
- Declines as DHEA declines
- adrenal insufficiency
- anorexia nervosa
- panhypopituitarism
High levels are often seen in PCOS and with over-supplementation.
Other causes of high Androsterone levels:
- DHEA, pregnenalone supplementation
- Androgen producing gonadal tumors
- Congenital adrenal hyperplasia
- Adult onset adrenal hyperplasia
- Serious illness/ shock - burns, etc.
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