Optimal Result: 2 - 26.2 mcg/g Creat..

Estrone is the predominant estrogen in post-menopausal women and inter-converts with estradiol. This conversion is dependant on the bidirectional activity of 17-beta-hydroxysteroid dehydrogenase, which also converts testosterone to androstenedione (an intermediate of androsterone, etiocholanolone, and estrone).

What does it mean if your Estrone (E1) (24hr) result is too low?

Why does estrogen decrease?

- Age (peri-menopause and menopause)

- Irregular cycles/skipped cycles/anovulation

- Hysterectomy with ovaries removed

- Anorexia

- Low cholesterol (backbone to hormones)

- Extreme exercise or training

- Extreme stress resulting in skipped menses

- Under appropriate body weight percentage for height/age

    • Mixed research: suggested <15% body fat = amenorrhea

- Hypogonadism (ovaries fail)

- Hypopituitarism (pituitary not communicating)

- Decreased blood flow to the ovaries

- Ex. Surgery or smokers

- Breast feeding

- Hypothyroidism

- PCOS

- Fertility medications

- Opioid pain medications (in last 6 months)

- Hormonal birth control – pill, patch, ring, implant, injection

What does it mean if your Estrone (E1) (24hr) result is too high?

Why do Estrogen levels increase?

1. Overweight/obesity

2. Peri-menopause = surges of estrogen

3. Diabetes

4. PCOS

5. Estrogen supplementation

6. Steroid medications

7. Poor liver clearance so estrogens build up

8. Dysbiosis/Estrobolome problems

9. Over aromatization from testosterone

10. Environmental estrogens (difficult to test however)

11. Alcohol (2 or more glasses/day shown to increase E)

12. Ovarian cysts

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