11-Keto-androsterone is a compound that is an end product of androgen catabolism.
In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group.
Androgens are important hormones in the health of both men and women. Testosterone and DHEA are metabolized into what is collectively known as the 17-ketosteroids (DHEA is formally included as a 17-ketosteroid). Together, these markers provide a comprehensive assessment of androgen sufficiency, as well as evaluating the need for, and monitoring of, androgen hormone therapy.
Lower level of Total 17-Ketosteroids may be associated with:
- Acute or chronic stress
- Aging, DHEA deficiency
- Excessive conversion of androgens to estrogens
- High estrogen level or estrogen replacement including oral contraceptives (can increase sex-hormone binding globulin, which reduces the amount of bioavailable androgens)
- Smoking, chronic alcohol ingestion
- Diabetes mellitus
- Ketoconazole, metformin, troglitazone
TREATMENT OPTIONS to increase Total 17-Ketosteroids:
- Stress management
- Increase dietary protein.
- Address aromatase imbalances.
- Consider supplementation with DHEA (15-100 mg/day) or other androgens.
Please talk to your doctor before starting any treatments.
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Higher level of Total 17-Ketosteroids may be associated with:
- DHEA, androstenedione, or testosterone supplementation
- High protein- or high calorie diet
- PCOS (especially with obesity) and/or hirsutism and/or acne
- Low sex-hormone binding globulin (e.g., from hyperinsulinemia or hypothyroidism)
- Aromatase inhibitors
- Congenital adrenal hyperplasia
- Tumors of adrenals, ovaries, or testes
TREATMENT OPTIONS to decrease Total 17-Ketosteroids:
- Improve insulin sensitivity.
- Correct thyroid imbalances.
Please talk to your doctor before starting any treatments.
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