There is evidence that methoxylated estrogens, especially the 2-pathway methoxylated estrogens (E1 and E2), are associated with decreased breast cancer risk; 2-MeOE2, produced from 2-OHE2, has been described to have anti-proliferative, antingiogenic, and pro-apoptotic activity in multiple types of cancer.
A high 2-OH(E1+E2) / 2-MeO(E1+E2) ratio may indicate less methylation activity and/or robust amount of hydroxylated compared to methylated analytes.
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