PCT is the volume occupied by platelets in the blood as a percentage and calculated according to the formula PCT = platelet count × MPV / 10,000 (25-27). Under physiological conditions, the amount of platelets in the blood is maintained in an equilibrium state by regeneration and elimination. The normal range for PCT is 0.22–0.24%. In healthy subjects, platelet mass is closely regulated to keep it constant, while MPV is inversely related to platelet counts. Genetic and acquired factors, such as race, age, smoking status, alcohol consumption, and physical activity, modify blood platelet count and MPV.
A low platelet count is known as thrombocytopenia. Thrombocytopenia can occur as a result of a separate disorder, such as leukemia or an immune system problem. Or it can be a side effect of taking certain medications.
Thrombocytopenia may be mild and cause few signs or symptoms. In rare cases, the number of platelets may be so low that dangerous internal bleeding occurs. Treatment options are available.
Thrombocytopenia signs and symptoms may include:
Easy or excessive bruising (purpura):
Purpura, also called blood spots or skin hemorrhages, refers to purple-colored spots that are most recognizable on the skin. The spots may also appear on organs or mucous membranes, including the membranes on the inside of the mouth.
Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs. Petechiae are tiny purple, red, or brown spots on the skin. They usually appear on your arms, legs, stomach, and buttocks. You might also find them inside your mouth or on your eyelids.
Prolonged bleeding from cuts
Bleeding from your gums or nose
Blood in urine or stools
Unusually heavy menstrual flows
In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin (a yellow pigment) in the blood—a condition called hyperbilirubinemia.
Thrombocytopenia can be inherited or it may be caused by a number of medications or conditions. Whatever the cause, circulating platelets are reduced by one or more of the following processes:
1. Trapped platelets
The spleen is a small organ about the size of your fist located just below your rib cage on the left side of your abdomen. Normally, your spleen works to fight infection and filter unwanted material from your blood. An enlarged spleen — which can be caused by a number of disorders — may harbor too many platelets, causing a decrease in the number of platelets in circulation.
2. Decreased production of platelets
Platelets are produced in your bone marrow. If production is low, you may develop thrombocytopenia. Factors that can decrease platelet production include:
3. Increased breakdown of platelets
Some conditions can cause your body to use up or destroy platelets more rapidly than they’re produced. This leads to a shortage of platelets in your bloodstream. Examples of such conditions include:
Dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets per microliter. Though rare, severe thrombocytopenia can cause bleeding into the brain, which can be fatal.
When to see a doctor
Make an appointment with your doctor if you have any warning signs that worry you. Bleeding that won’t stop is a medical emergency. Seek immediate help if you experience bleeding that can’t be controlled by the usual first-aid techniques, such as applying pressure to the area.
What could it mean if Plateletcrit value is high?
In previous studies it was demonstrated that PCT was highest in patients with:
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