Large unstained cells (LUC) are cells that can’t be called stem cells, normal lymphocytes (white blood cells) or virocytes. Clinical laboratories running blood and other medical tests will report on the percentage of large unstained cells on their test results. They are actually activated lymphocytes and peroxidase-negative cells.
In one study, researchers found that the percentage of LUC significantly increased in a group of patients with HIV who had no symptoms of the disease and were not being treated for it. The increase in the percentage correlated with the CD4 counts and markers of immune system activation. Thus, the LUC test may be a valuable test in identifying HIV patients who could have a rapid progression in their disease.
Other researchers report that the large unstained cells could mean viral infection, leukemia, or fungal infection such as aspergillosis. In one study, researchers found that when the percentage of large unstained cells increased, the markers of inflammation in the body also increased. This study was done in patients with aspergillosis fungal infections.
Normal Ranges for Large Unstained Cells (LUC) in number x 10E3/uL:
Optimal range: 0-0.4 x10E3/uL
Sources:
There is no known correlation to health issues with low levels of large unstained cells.
Some specific causes of high levels of large unstained cells could be due to:
- Viral infections, such as HIV (Not all viruses cause the increase in large unstained cells.)
- Fungal infections, such as aspergillosis
- Leukemia
- Inflammation
- Chronic renal failure
- Malaria
- Postoperative response
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn MoreAt HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Alpha-1-Antitrypsin, Serum, Ammonia, Angiotensin-1-Converting Enzyme, Beta-2 Glycoprotein I Ab, IgA, Bicarbonate (HCO3), Serum, C-Reactive Protein (CRP), D-Dimer, Erythropoietin (EPO), Serum, Factor IX Activity, Factor VII Activity, Factor VIII Activity, Factor X Activity, Factor XI Activity, Ferritin, Ferritin (female range), Fibrinogen Activity, Fibrinogen Antigen, Haptoglobin, Immature Platelet Fraction, Iron, IRON (Serum), Lactate Dehydrogenase (LDH or LD), Large Unstained Cells (LUC), Large Unstained Cells (Percent), Magnesium, RBC, Nucleated red blood cell (NRBC), Plateletcrit (PCT), Reticulocyte Count, Reticulocyte, Absolute, Thrombocytes, Total iron-binding capacity (TIBC), Transferrin, Transferrin saturation (Iron Saturation), UIBC