The Factor VII protein is part of the cascade of clotting factors that form the chain leading to a protective blood clot. Factor VII deficiency is usually severe. In fact, patients with less than 1% Factor VII activity experience similar symptoms to hemophilia.
- Congenital factor VII deficiency is rare and is inherited as one of several autosomal recessive mutations.
- Acquired factor VII deficiency is caused by liver disease, vitamin K deficiency or the use of Coumadin (warfarin) therapy.
- Factor VII deficiency is associated with moderate to severe bleeding.
- The combination of a prolonged prothrombin time and normal partial thromboplastin time may indicate factor VII deficiency.
People with severe factor VII deficiency:
- Are prone to joint bleeds
- In addition to spontaneous nosebleeds, people can experience bleeds in the stomach, intestines and urinary tract
- Head bleeds and muscle bleeds have also been reported
- Women can have severe menorrhagia
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