Other names for this marker:
– β2-Glycoprotein 1 Antibodies, IgA
– Beta-2 Glycoprotein 1 Antibodies, IgA
– Beta-2 Glycoprotein 1 Antibodies, IgA, Serum
– beta-2 GP1 IgA antibodies
– Beta 2GP1 Ab
– Beta-2-Glycoprotein I Antibodies (IgA)
Beta-2 glycoprotein 1 antibody is an autoantibody that is associated with inappropriate blood clotting. This test detects and measures one class (IgA) of beta-2 glycoprotein 1 antibodies.
Beta-2 glycoprotein antibody is considered one of the primary autoantibodies called antiphospholipid antibodies that mistakenly target the body’s own lipid-proteins (phospholipids) found in the outermost layer of cells (cell membranes) and platelets.
Antiphospholipid antibodies interfere with the body’s blood clotting process in a way that is not fully understood. Their presence increases a person’s risk of developing inappropriate blood clots (thrombi) in both arteries and veins. Antiphospholipid antibodies are most frequently seen in people with the autoimmune disorder called antiphospholipid syndrome (APS), which is associated with blood clots (thrombotic episodes), a low platelet count (thrombocytopenia), or with pregnancy complications such as pre-eclampsia and recurrent miscarriages, especially in the second and third trimesters.
One or more antiphospholipid antibodies may also be seen with other autoimmune disorders, such as lupus (systemic lupus erythematosus, SLE).
The beta-2 GP-1 antibody test may be ordered when there is an unexplained blood clot in a vein or artery. Other symptoms may include shortness of breath, pain and swelling of the extremities and headaches.
Here are a few other reasons for performing this test:
– Unexplained arterial or venous thrombosis
– A history of pregnancy morbidity
– Presence of an unexplained cutaneous circulatory disturbance
– Unexplained thrombocytopenia or hemolytic anemia
– Possible nonbacterial, thrombotic endocarditis
References:
– http://www.eurjrheumatol.org/sayilar/204/buyuk/135-138.pdf
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This test detects and measures one class of the autoantibodies (IgA). The test is used for the diagnosis of antiphospholipid syndrome (APS), to detect autoantibodies in a person diagnosed with an autoimmune disorder, to identify the cause of recurrent miscarriages, to diagnose the cause of unexplained thrombotic episodes.
If high levels of beta-2 GP-1 antibody is detected initially and again after a period of 12 weeks and the person shows signs of APS, then it is likely that the person has the disorder. If a person diagnosed with another autoimmune disorder, has high beta-2 glycoprotein antibodies, the risk of developing a clot in a blood vessel is high.
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11dhTxB2/Creatinine (AspirinWorks), Absolute Reticulocytes, Alpha-1 Antitrypsin Phenotype, Alpha-1-Antitrypsin, Serum, Ammonia, Angiotensin-1-Converting Enzyme, Beta-2 Glycoprotein I Ab, IgA, Beta-2 Glycoprotein I, IgG, Beta-2 Glycoprotein I, IgM, Bicarbonate (HCO3), Serum, C-Reactive Protein (CRP), C-Reactive Protein, Cardiac, Copper, Serum or Plasma, D-Dimer, D-Dimer, Quantitative, Delta Aminolevulinic Acid, Urine, 24 Hour, Erythropoietin (EPO), Serum, F2-Isoprostane, Factor IX Activity, Factor V Leiden Mutation, Factor VII Activity, Factor VIII Activity, Factor X Activity, Factor XI Activity, Ferritin, Ferritin (female range), Fibrinogen Activity, Fibrinogen Antigen, Glucose 6-Phosphate Dehydrogenase (G6PD), Quantitative, Haptoglobin, Hemoglobin A, Hemoglobin F, Immatue Reticulocyte Fraction, Immature Platelet Fraction, Immature Retic Fraction, Iron, IRON (Serum), Lactate Dehydrogenase (LDH or LD), Large Unstained Cells (LUC), Large Unstained Cells (Percent), Macrocytosis, Magnesium, RBC, Nucleated RBC (NRBC) (%), Nucleated red blood cell (NRBC), OxPL-apoB1, Plasminogen Activator Inhibitor 1 (PAI-1) Activity, Platelet Ab, Indirect (IgA), Platelet Ab, Indirect (IgG), Platelet Ab, Indirect (IgM), Plateletcrit (PCT), Polychromasia, Porphobilinogen Deaminase, Whole Blood, Porphyrins, Total Serum, PTT-LA Screen, Retic Hgb Equivalent, Reticulocyte Count, Reticulocyte hemoglobin, Reticulocyte, Absolute, Sickle Cell Screen, Stomatocytes, Thrombin Antithrombin Complex, Thrombocytes, Total iron-binding capacity (TIBC), Transferrin, Transferrin Receptor, Transferrin saturation (Iron Saturation), UIBC
