Beta-2 Glycoprotein I Ab, IgA

Other names for this marker:

– β2-Glycoprotein 1 Antibodies, IgA

– Beta-2 Glycoprotein 1 Antibodies, IgA

– Beta-2 Glycoprotein 1 Antibodies, IgA, Serum

– beta-2 GP1 IgA antibodies

– Beta 2GP1 Ab

– Beta-2-Glycoprotein I Antibodies (IgA)

Beta-2 glycoprotein 1 antibody is an autoantibody that is associated with inappropriate blood clotting. This test detects and measures one class (IgA) of beta-2 glycoprotein 1 antibodies.

Beta-2 glycoprotein antibody is considered one of the primary autoantibodies called antiphospholipid antibodies that mistakenly target the body’s own lipid-proteins (phospholipids) found in the outermost layer of cells (cell membranes) and platelets.

Antiphospholipid antibodies interfere with the body’s blood clotting process in a way that is not fully understood. Their presence increases a person’s risk of developing inappropriate blood clots (thrombi) in both arteries and veins. Antiphospholipid antibodies are most frequently seen in people with the autoimmune disorder called antiphospholipid syndrome (APS), which is associated with blood clots (thrombotic episodes), a low platelet count (thrombocytopenia), or with pregnancy complications such as pre-eclampsia and recurrent miscarriages, especially in the second and third trimesters.

One or more antiphospholipid antibodies may also be seen with other autoimmune disorders, such as lupus (systemic lupus erythematosus, SLE).

The beta-2 GP-1 antibody test may be ordered when there is an unexplained blood clot in a vein or artery. Other symptoms may include shortness of breath, pain and swelling of the extremities and headaches.

Here are a few other reasons for performing this test:

– Unexplained arterial or venous thrombosis

– A history of pregnancy morbidity

– Presence of an unexplained cutaneous circulatory disturbance

– Unexplained thrombocytopenia or hemolytic anemia

– Possible nonbacterial, thrombotic endocarditis

References:

– http://www.eurjrheumatol.org/sayilar/204/buyuk/135-138.pdf