Oxidized phospholipids are found on all apoB-containing lipoproteins, namely, LDL, VLDL, and especially Lp(a). When taken up by the artery wall, oxidized lipoproteins accelerate atherosclerosis, thereby, increasing the risk of myocardial infarctions, strokes, and calcific aortic valve stenosis. Oxidized phospholipids are highly pro-inflammatory and contribute to many diseases of aging.
Clinicians can use OxPL-apoB levels to reclassify patients into higher or lower risk categories allowing better personalized care.
Optimal: <2.0 nM/L
Borderline: 2.0-3.0 nM/L
Increased Risk: >3.0 nM/L
References:
Tsimikas S et al. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. J Am Coll Cardiol. 2010; 56:946-955.
Tsimikas S at al. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol. 2012; 60:2218-2229.
Byun YS et al. Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: The TNT Trial. J Am Coll Cardiol. 2015; 65:1286-1295.
Kamstrup PR et al. Oxidized phospholipids and risk of calcific aortic valve disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017; 37:1570-1578.
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Two- to three-fold increased CVD risk is seen in individuals with an OxPL-apoB value > 7.5 nmol/L as compared to those with values below this threshold.
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Alpha-1-Antitrypsin, Serum, Ammonia, Angiotensin-1-Converting Enzyme, Beta-2 Glycoprotein I Ab, IgA, Beta-2 Glycoprotein I, IgG, Beta-2 Glycoprotein I, IgM, Bicarbonate (HCO3), Serum, C-Reactive Protein (CRP), D-Dimer, Erythropoietin (EPO), Serum, F2-Isoprostane, Factor IX Activity, Factor VII Activity, Factor VIII Activity, Factor X Activity, Factor XI Activity, Ferritin, Ferritin (female range), Fibrinogen Activity, Fibrinogen Antigen, Haptoglobin, Immature Platelet Fraction, Iron, IRON (Serum), Lactate Dehydrogenase (LDH or LD), Large Unstained Cells (LUC), Large Unstained Cells (Percent), Magnesium, RBC, Nucleated red blood cell (NRBC), OxPL-apoB1, Plateletcrit (PCT), PTT-LA Screen, Reticulocyte Count, Reticulocyte, Absolute, Thrombocytes, Total iron-binding capacity (TIBC), Transferrin, Transferrin saturation (Iron Saturation), UIBC
