Immature platelets can be a useful marker of thrombopoietic activity.
They represent the most recently produced platelets released into the circulation by regenerated BM megakaryocytes. These types of platelets are the analogs of reticulocytes and are similarly large; moreover, they contain elevated amounts of cytoplasmic RNA and decrease in size and RNA content as they age. The number and proportion of immature platelets reflect the rate of thrombopoiesis; the values of these parameters rise and fall concomitantly with the platelet production rate.
References:
Jeon K, Kim M, Lee J, Lee JS, Kim HS, Kang HJ, Lee YK. Immature platelet fraction: A useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery. Medicine. 2020 99 7(e19096). [L]
Kickler TS, Oguni S, Borowitz MJ. Clinical evaluation of high fluorescent platelet fraction percentage in thrombocytopenia. Am J Clin Pathology 2006 125 282 287. [L]
IPF reflects the bone marrow thrombopoietic activity, increasing when platelet production rises and decreasing when production falls.
Thus, IPF is useful in determining whether the thrombocytopenia is secondary to decreased production (aplastic causes) or peripheral platelet destruction (such as ITP or TTP).
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IPF reflects the bone marrow thrombopoietic activity, increasing when platelet production rises and decreasing when production falls.
Thus, IPF is useful in determining whether the thrombocytopenia is secondary to decreased production (aplastic causes) or peripheral platelet destruction (such as ITP or TTP).
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Alpha-1-Antitrypsin, Serum, Ammonia, Angiotensin-1-Converting Enzyme, Beta-2 Glycoprotein I Ab, IgA, Beta-2 Glycoprotein I, IgG, Beta-2 Glycoprotein I, IgM, Bicarbonate (HCO3), Serum, C-Reactive Protein (CRP), D-Dimer, Erythropoietin (EPO), Serum, Factor IX Activity, Factor VII Activity, Factor VIII Activity, Factor X Activity, Factor XI Activity, Ferritin, Ferritin (female range), Fibrinogen Activity, Fibrinogen Antigen, Haptoglobin, Immature Platelet Fraction, Iron, IRON (Serum), Lactate Dehydrogenase (LDH or LD), Large Unstained Cells (LUC), Large Unstained Cells (Percent), Magnesium, RBC, Nucleated red blood cell (NRBC), Plateletcrit (PCT), PTT-LA Screen, Reticulocyte Count, Reticulocyte, Absolute, Thrombocytes, Total iron-binding capacity (TIBC), Transferrin, Transferrin saturation (Iron Saturation), UIBC
