Arachidonic acid is an inflammatory omega-6 fatty acid. Our bodies produce this nutrient, and its excess may lead to inflammatory diseases and mood disorders.
Because of the prevalence of corn and corn oil products in feed for cattle and hogs, diets high in these animal products are rich in arachidonic acid.
Arachidonic acid is found in animal products, like poultry and eggs. The amount of arachidonic acid found in just one egg a day elevated arachidonic acid levels in the bloodstream, Japanese researchers learned.
Food sources of arachidonic acid, listed in descending order by percentages of their contribution to intake:
| Rank | Food item | Contribution to intake (%) | Cumulative contribution (%) |
|---|---|---|---|
| 1 | Chicken and chicken mixed dishes | 26.9 | 26.9 |
| 2 | Eggs and egg mixed dishes | 17.8 | 44.7 |
| 3 | Beef and beef mixed dishes | 7.3 | 52.0 |
| 4 | Sausage, franks, bacon, and ribs | 6.7 | 58.7 |
| 5 | Other fish and fish mixed dishes | 5.8 | 64.5 |
| 6 | Burgers | 4.6 | 69.1 |
Arachidonic acid is a 20-carbon or fatty acid that serves as the principal pro-inflammatory fatty acid. Its synthesis is inhibited by non-steroidal anti-inflammatory drugs (NSAIDs).
Arachidonic Acid and Mental Health:
Arachidonic acid may trigger brain inflammation. High blood levels have been associated with a greater risk of suicide and depressive episodes. On the other hand, diets high in carbohydrate and low in fat and protein (with little or no arachidonic acid) may be associated with lower levels of anxiety and depression, according to epidemiological studies.
In one study, overweight or diabetic employees who went on a whole food, plant-based diet reported increased energy, better sleep patterns and improved mental health compared to a control group given no diet restrictions. Their work productivity also showed improvement.
A similar subsequent study of employees at 10 corporate sites showed notable improvements in depression, anxiety and emotional well-being among those following a meat-free, plant-based diet.
Arachidonic Acid and Inflammatory Bowel Disease:
Animal protein from meat and fish has also been associated with a higher risk of inflammatory bowel disease such as ulcerative colitis and Crohn’s disease. Arachidonic acid has been identified as one possible reason why. Even a semi-vegetarian diet has been shown to be highly beneficial in preventing relapses among patients suffering from Crohn’s disease.
References:
- https://epi.grants.cancer.gov/diet/foodsources/fatty_acids/table4.html
- https://nutritionfacts.org/topics/arachidonic-acid/
- https://www.ncbi.nlm.nih.gov/pubmed?term=20950616[uid]
- https://www.ncbi.nlm.nih.gov/pubmed/18774339
- https://www.ncbi.nlm.nih.gov/pubmed/12548439
Reduced intake of animal meats and fats, or low dietary intake of omega-6 fatty acids in general, can result in lower levels of AA. Lack of vitamin and mineral cofactors for the desaturase and elongase enzymes upstream in omega-6 metabolism might contribute to lower levels.
Because of important immune and inflammatory signaling which requires AA, and its role in cell membrane phospholipid metabolism, lower levels of AA do have clinical significance. Psychiatric disorders such as schizophrenia, and neurologic disorders like tardive dyskinesia, show depletion of AA in RBC membranes. Improving AA levels decreased symptoms in some patients.
Monitoring levels and ensuring adequate dietary intake of AA is important in pregnant women, infants, children, and the elderly due to its importance for the development and optimization of the nervous system, skeletal muscle, and the immune system.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
- A high Arachidonic acid level promotes gallstone formation by stimulating mucin production in the gallbladder mucosa.
- Arachidonic acid may trigger brain inflammation. High blood levels have been associated with a greater risk of suicide and depressive episodes.
- Animal protein from meat and fish has also been associated with a higher risk of inflammatory bowel disease such as ulcerative colitis and Crohn’s disease. Arachidonic acid has been identified as one possible reason why.
Potential treatment:
Reduce or eliminate consumption of animal products.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.
Get Started
Get Started With Our Personal Plan
Advanced Plan
Unlimited Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Plan
for health professionals
$45 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
11-Eicosenoic, 25-Hydroxyvitamin D, a-Hydroxybutyric Acid, AA/EPA, Alpha Linolenic, alpha-Tocopherol, Aluminum, Arachidic, Arachidonic, Arsenic, Behenic, Beta-Carotene, Cadmium, Calcium, Capric, Coenzyme Q10 (Genova), Copper, Creatinine, Dihomogamma Linolenic (Genova), Docosadienoic (Genova), Docosahexaenoic (Genova), Docosapentaenoic (Genova), Docosatetraenoic (Genova), Eicosadienoic (Genova), Eicosapentaenoic (Genova), EPA/DGLA (Genova), Gamma Linolenic (Genova), gamma-Tocopherol (Genova), Glyceric Acid, Glycolic, Heneicosanoic (Genova), Heptadecanoic (Genova), Hexacosanoic (Genova), LA/DGLA, Lauric (Genova), Lead (Genova), Lignoceric (Genova), Linoleic (Genova), Lipid Peroxides (Genova), Magnesium (Genova), Mead (Genova), Mercury (Genova), Myristic (Genova), Myristoleic (Genova), Nervonic (Genova), Nonadecanoic (Genova), Oleic (Genova), Oxalic Acid, Palmitelaidic, Palmitic (Genova), Palmitoleic (Genova), Pentadecanoic (Genova), Potassium (Genova), Selenium (Genova), Stearic (Genova), Stearic/Oleic, Total C:18 Trans, Tricosanoic (Genova), Triene/Tetraene (Genova), Vaccenic, Vitamin A (Retinol) (Genova), Zinc (Genova)
