Urinary creatinine is commonly used as a laboratory standardization when evaluating urinary analytes.
Creatinine excretion is influenced by muscle mass and body habitus since creatinine formation occurs in muscle.
Dietary intake of proteins containing arginine and glycine (precursors of creatine) and creatine supplementation can elevate levels.
Hydration status may also play a role in urinary creatinine levels.
References:
Armstrong MD, Shaw K, Wall P. The phenolic acids of human urine. J Biol Chem. 1956;218:293. [L]
Cocker J, Mason HJ, Warren ND, Cotton RJ. Creatinine adjustment of biological monitoring results. Occup Med. 2011;61(5):349-353. [L]
Garde Ah, Hansen Åm, Kristiansen J, Knudsen Le. Comparison of Uncertainties Related to Standardization of Urine Samples with Volume and Creatinine Concentration. Ann Occup Hyg. 2004;48(2):171-179. [L]
Baxmann AC, Ahmed MS, Marques NC, et al. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. CJASN. 2008;3(2):348-354. [L]
Hydration status may play a role in urinary creatinine levels.
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Dietary intake of proteins containing arginine and glycine (precursors of creatine) and creatine supplementation can elevate levels.
Hydration status may also play a role in urinary creatinine levels.
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