Genova Diagnostics

a-Hydroxybutyric Acid

Optimal Result: 0 - 0.83 mmol/mol creatinine.

a-hydroxybutyric acid (2-hydroxybuturic acid [2-HB]) is a marker that relates to oxidative stress.

a-hydroxybutyric acid is an organic acid produced from a-ketobutyrate via the enzymes lactate dehydrogenase (LDH) or a-hydroxybutyrate dehydrogenase (HBDH).

These enzymes are catalyzed by NADH. Oxidative stress creates an imbalance in NADH/NAD ratios, which leads directly to the production of a-hydroxybutyric acid. Being that a-hydroxybutyric acid’s precursor a-ketobutyrate is a byproduct in the glutathione (GSH) synthesis pathway, an increased demand for GSH may ultimately result in increased a-hydroxybutyric acid.

Increased oxidative stress associated with insulin resistance increases the rate of hepatic glutathione synthesis. Plasma a-hydroxybutyric acid is highly associated with insulin resistance and may be an effective biomarker for prediabetes.

A study on type 2 diabetics showed that GSH infusion restored the NADH/NAD balance and resulted in improvement of insulin sensitivity and beta cell function.

References:

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565252/

- https://pubmed.ncbi.nlm.nih.gov/20526369/

- https://pubmed.ncbi.nlm.nih.gov/1737525/

- https://pubmed.ncbi.nlm.nih.gov/168632/

What does it mean if your a-Hydroxybutyric Acid result is too low?

There are no known clinical associations with low levels of a-hydroxybutyric acid.

What does it mean if your a-Hydroxybutyric Acid result is too high?

Higher circulating levels of a-Hydroxybutyric Acid are associated with insulin resistance and prediabetes.

Elevated a-hydroxybutyric acid may be seen with oxidative stress.

Treatment options:

Evaluate oxidative stress markers such as lipid peroxides and 8-hydroxydeoxyguanosine (8-OHdG) and ensure adequate antioxidant intake and glutathione status. Hard physical exercise can result in lactic acidosis and accumulation of 2-HB.

If you can test it, we can track it — all test results, including the ones from your favorite labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 2000+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;