Globulin, Serum

Liver Health

A healthy result should fall into the range 2.2 - 3.9 g/dL.

The main two types of protein in your blood are albumin, the main carrier protein, and globulin, the main immune protein. Low levels of globular protein can weaken your immunity, while higher levels can indicate increased inflammation in the body.

Globulins are produced by the liver and the immune system. Albumin makes up more than half of the total protein within the blood, and globulins make up the remainder. Globulins have multiple different functions; the group includes immunoglobulins, enzymes, carrier proteins and complement.

There are four groups of globulins. Serum protein electrophoresis is the test used to distinguish one from another and establish levels of each within the bloodstream.

Alpha 1 globulins

  • Mainly alpha-1 antitrypsin.

Alpha 2 globulins

  • Alpha 2 macroglobulin.
  • Haptoglobin.

Beta globulins

  • Transferrin.
  • Complement components C3, C4, C5.

Gamma globulins

Mostly immunoglobulins (antibodies):

  • IgG: majority of the immunoglobulin component. Many antibodies to bacteria and viruses are IgG.
  • IgE: involved in allergic response. Triggers histamine release. Also protects against parasites.
  • IgM: largest antibodies and first type produced in response to infection.
  • IgD: exists in very small quantities in blood. Function not very well understood.
  • IgA: found in mucous membranes, blood, saliva and tears. Protect body surfaces which are exposed to foreign substances.


Globulin, Serum result calculator

insert the value from you Globulin, Serum test result.

What does it mean if your Globulin, Serum result is too low?

  • Malnutrition (due to decreased synthesis).
  • Congenital immune deficiency (due to decreased synthesis).
  • Nephrotic syndrome (due to protein loss through the kidneys).
  • Increased albumin level causing decreased globulin fraction - eg, acute dehydration.

What does it mean if your Globulin, Serum result is too high?

  • Acute infection.
  • Chronic inflammatory disease - eg, rheumatoid arthritis, systemic lupus erythematosus (SLE).
  • Multiple myeloma.
  • Waldenström's macroglobulinaemia.
  • Hyperimmunisation.
  • Low albumin level causing increased globulin fraction - cirrhosis, nephrotic syndrome.

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