Optimal Result:
1.5 - 4.5 g/dL,
or
15 - 45 g/L.
What is globulin?
Globulin is a protein and is made in the liver. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease.
About 40% of the proteins in your blood are alpha, beta and gamma globulins. Albumin is the other common blood protein.
Globulin forms the main transport system for various substances as well as a constituant of the antibody system (“immunoglobulins”) that fights infections and viruses. Globulins are also needed to form blood clots and keep the liver and kidneys functioning.
The globulin value on the chemistry panel is not measured, but is calculated by the equation: Globulins = Total protein – Albumin.
There are four groups of globulins. Serum protein electrophoresis is the test used to distinguish one from another and establish levels of each within the bloodstream.
Alpha 1 globulins:
- Mainly alpha-1 antitrypsin.
Alpha 2 globulins:
- Alpha 2 macroglobulin.
- Haptoglobin.
Beta globulins:
- Transferrin.
- Complement components C3, C4, C5.
Gamma globulins:
Mostly immunoglobulins (antibodies)
- IgG: majority of the immunoglobulin component. Many antibodies to bacteria and viruses are IgG.
- IgE: involved in allergic response. Triggers histamine release. Also protects against parasites.
- IgM: largest antibodies and first type produced in response to infection.
- IgD: exists in very small quantities in blood. Function not very well understood.
- IgA: found in mucous membranes, blood, saliva and tears. Protect body surfaces which are exposed to foreign substances.
Why test proteins in blood (serum)?
Hundreds of proteins are dissolved in the plasma. By measuring the concentration of these proteins, the clinician can obtain information regarding disease states in different organ systems. The measurement of protein is done on serum, which is the fluid that remains after plasma has clotted, thus removing fibrinogen and most of the clotting factors. Total protein content provides some information regarding a patient's general status; more clinically useful data are obtained from fractionating the total protein. The normal serum protein level is 6 to 8 g/dl. Albumin makes up 3.5 to 5.0 g/dl, and the remainder is the total globulins. These values may vary according to the individual laboratory.
Proteins are vital to the functioning of virtually all parts of the body. The most common protein in the blood is albumin, which prevents fluid from leaking and carrying substances through the body.
Almost all of the other proteins in the blood are globulins, formed by the immune system and by the liver. There are several kinds of globulins, but a basic total protein test usually will not measure the amounts of each specific type.
A blood test of total proteins will often directly measure albumin. This allows for calculating the number of globulins by subtracting albumin from total protein. It also allows for a calculation of the A/G ratio.
When is a globulin test ordered?
A globulin test is ordered as part of a routine physical exam (“Complete Metabolic Panel”) to identify potential liver and kidney problems or to monitor disease progression.
A globulin test may be part of liver function tests, metabolic panel, total protein test or serum protein electrophoresis.
Your healthcare provider may order tests to see how your liver is working if you have symptoms such as:
Globulin tests can be used to help diagnose a variety of conditions, including:
Globulin proteins are important to liver and kidney function. A total protein test is a good indication of how the liver is working. Low total protein levels can be a sign of liver disease. While globulin blood tests can help a healthcare provider to make a diagnosis, they will also use other tests and evaluations to diagnose a specific condition or illness.
What is the normal range for a globulin test?
Protein globulin levels for adults normally fall between 1.5 - 4.5 g/dL. The normal range for total protein is between 6.4 and 8.3 g/dL.
If the results are normal, you won't need any specific follow-up for the test. However, your healthcare provider may want to run other types of tests if you are having symptoms.
If the results are outside the normal range, your healthcare provider may have you do additional blood tests to provide more specific information. Or, you may need imaging tests like an MRI to look for tumors or swollen lymph nodes if cancer is suspected.
What is the A/G ratio?
A total protein test also shows the ratio of albumin to globulin or A/G ratio. The A/G ratio is a measure of the amount of albumin proteins in blood compared to globulins. Typically, your body has slightly more albumin than globulins. A normal A/G ratio is slightly more than 1.
References:
Busher JT. Serum Albumin and Globulin. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 101. Available from: https://www.ncbi.nlm.nih.gov/books/NBK204/
Hashash JG, Koutroumpakis F, Anderson AM, Rivers CR, Hosni M, Koutroubakis IE, Ahsan M, Gkiaouraki E, Dunn MA, Schwartz M, Barrie A, Babichenko D, Tang G, Binion DG. Elevated serum globulin fraction as a biomarker of multiyear disease severity in inflammatory bowel disease. Ann Gastroenterol. 2022 Nov-Dec;35(6):609-617. doi: 10.20524/aog.2022.0748. Epub 2022 Oct 3. PMID: 36406970; PMCID: PMC9648529.
Jolles S, Borrell R, Zouwail S, Heaps A, Sharp H, Moody M, Selwood C, Williams P, Phillips C, Hood K, Holding S, El Shanawany T. Calculated globulin (CG) as a screening test for antibody deficiency. Clin Exp Immunol. 2014 Sep;177(3):671-8. doi: 10.1111/cei.12369. PMID: 24784320; PMCID: PMC4137851.
Links:
- https://www.cancer.org/cancer/types/multiple-myeloma/about/what-is-multiple-myeloma.html
- Loh RK, Vale S, McLean-Tooke A; Quantitative serum immunoglobulin tests. Aust Fam Physician. 2013 Apr42(4):195-8.
- Bird JM; Investigating an incidental finding of a paraprotein. BMJ. 2012 May 4344:e3033. doi: 10.1136/bmj.e3033.
- Immunoglobulin; Public Health England
- Busher JT; Serum Albumin and Globulin
- Serum globulin electrophoresis; MedlinePlus
- Monoclonal gammopathy of undetermined significance (MGUS); Melbourne Haematology
- Immunoelectrophoresis - blood; MedlinePlus
High globulin levels may be a sign of:
Abnormal results may also be caused by certain medicines, dehydration, pregnancy, or other conditions.
Any increase or decrease in the globulin fraction should be evaluated by serum electrophoresis. The pattern should be visually inspected for abnormalities in particular regions.
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
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→ Malnutrition (a lack of protein in the diet can cause low globulin levels),
→ Congenital immune deficiency (aka congenital immunodeficiency or primary immunodeficiency is a genetic defect that prevents children from producing enough immune cells or substances to help protect the body against infections.)
→ Chronic inflammation (can affect the production and distribution of globulin in the body)
→ Liver disease (liver produces many of the proteins in the body, including globulin. Certain liver diseases, such as cirrhosis, can impair the liver's ability to produce globulin.)
→ Kidney (kidneys help regulate the balance of proteins in the body. If the kidneys are not functioning properly, it can result in low globulin levels.)
→ Nephrotic syndrome (a kidney disorder that causes your body to pass too much protein in your urine)
→ Autoimmune disorders (such as lupus and rheumatoid arthritis)
→ Genetic disorders (genetic disorders, such as X-linked agammaglobulinemia, can cause low levels of globulin.)
Any increase or decrease in the globulin fraction should be evaluated by serum electrophoresis. The pattern should be visually inspected for abnormalities in particular regions.
Laboratories
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Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
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Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
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Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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Unlimited Plan Member since 2021
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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