Other names: A/G Ratio, ALBUMIN/GLOBULIN RATIO, Albumin/ Globulin Ratio
Optimal Result:
1.2 - 2.2 Ratio.
What is the Albumin/Globulin Ratio?
The Albumin to Globulin ratio (A:G) is the ratio of albumin present in serum in relation to the amount of globulin. Serum is the clear fluid part of blood that contains no blood cells and clotting components. This serum contains proteins, which are known as serum protein.
Serum protein consists of main proteins:
Albumin proteins: Albumin, which makes up 50 percent of serum protein, reflects your nutritional status. Albumin proteins transport substances like hormones, fatty acids, and drugs throughout your body.
Globulin proteins: Globulin proteins, which are made by your immune system, make up around 48 percent of serum protein. These proteins indicate the state of your immune function and the severity of any inflammationTrusted Source.
The ratio can be interpreted only in light of the total protein concentration. Very generally speaking, the normal ratio in most species approximates 1:1. For example, high total protein with a normal A:G ratio suggests dehydration, while the same protein with a low A:G ratio would indicate hyperglobulinemia (= an abnormally high concentration of globulins in the circulating blood plasma).
Typically, an A/G ratio test is done as part of a routine protein blood test. It’s used to check your general health, including nutritional status and immune function.
What does the Albumin/Globulin Ratio measure?
An A/G ratio test measures albumin and globulin, the two main proteins in your blood. This simple blood test is used to monitor your nutritional status, immune function, and overall health.
What do Albumin/Globulin results mean?
The normal range for albumin/globulin ratio is over 1, usually around 1 to 2. That’s because there’s a bit more albumin than globulin in serum protein.
If your body is producing too much or too little of either protein, your A/G ratio will be classified as high or low.
High or low A/G ratios are particularly associated with kidney and liver disease. A low A/G ratio can also indicate chronic infections, cancers, and more. A high A/G ratio is associated with dehydration, malnutrition, and other gastrointestinal conditions.
Serum albumin/globulin ratio (AGR) has been shown in several recent studies to be able to predict the prognosis of a number of illnesses, including cancer, chronic renal disease, heart failure, low thyroid activity, and peritoneal dialysis. If your doctor feels any of your levels are too high or low, you may need to have more precise blood or urine tests.
These tests can be used to check on the condition of your liver or kidneys if you have already experienced an aberrant test result or have been previously diagnosed with an underlying problem. Additionally, testing can be used to keep track of prescription drug side effects that may have an influence on the liver or kidneys.
Your doctor might check your A/G ratio if you’re experiencing unexplained weight loss, extreme fatigue, or swelling.
What is Albumin and what are its functions?
The most prevalent plasma protein produced by the liver is Albumin. Blood leaks from blood arteries are prevented by Albumin. Additionally, it aids in the movement of hormones, medications, vitamins, and other critical elements throughout the body. The liver is where Albumin is produced.
What are globulins and what are their functions?
The majority of the blood's other proteins are globulins. Globulins transport nutrients throughout the body and aid in the fight against infection. The liver creates some globulins. The immune system produces others. It is less water soluble than Albumin. The terms alpha, beta, and gamma globulins refer to several types of globulins.
When is the Albumin/Globulin Ratio tested?
A comprehensive metabolic panel test frequently includes a total protein and albumin/globulin (A/G) ratio test to evaluate the Protein in the blood. The test can help diagnose several kinds of health problems, including liver and kidney disease, as well as nutritional deficiencies.
The test also compares the levels of Globulin and Albumin in your blood. The ratio between Albumin and Globulin is referred to as the A/G ratio. If your A/G ratio or total protein levels are abnormal, this could indicate a major health issue.
This blood test is also used to screen and monitor various health conditions, including kidney disease, chronic infections, various cancers, and more.
If you experience symptoms that point to aberrant protein levels, you could also require this test. These include:
References:
Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol. 2006 Jun;41(6):759-60. doi: 10.1080/00365520500442625. PMID: 16716979.
Thakkinstian A, Tran H, Reeves G, Murch S, Attia J. A clinical decision rule to aid ordering of serum and urine protein electrophoresis for case-finding of paraproteins in hospitalized inpatients. J Gen Intern Med. 2008 Oct;23(10):1688-92. doi: 10.1007/s11606-008-0712-z. Epub 2008 Jul 30. PMID: 18665429; PMCID: PMC2533374.
Bae JC, Seo SH, Hur KY, Kim JH, Lee MS, Lee MK, Lee WY, Rhee EJ, Oh KW. Association between Serum Albumin, Insulin Resistance, and Incident Diabetes in Nondiabetic Subjects. Endocrinol Metab (Seoul). 2013 Mar;28(1):26-32. doi: 10.3803/EnM.2013.28.1.26. Epub 2013 Mar 25. PMID: 24396647; PMCID: PMC3811792.
Cho HM, Kim HC, Lee JM, Oh SM, Choi DP, Suh I. The association between serum albumin levels and metabolic syndrome in a rural population of Korea. J Prev Med Public Health. 2012 Mar;45(2):98-104. doi: 10.3961/jpmph.2012.45.2.98. Epub 2012 Mar 31. PMID: 22509450; PMCID: PMC3324721.
Kadono M, Hasegawa G, Shigeta M, Nakazawa A, Ueda M, Yamazaki M, Fukui M, Nakamura N. Serum albumin levels predict vascular dysfunction with paradoxical pathogenesis in healthy individuals. Atherosclerosis. 2010 Mar;209(1):266-70. doi: 10.1016/j.atherosclerosis.2009.09.006. Epub 2009 Sep 12. PMID: 19819455.
JEEJEEBHOY KN, BOUCHER BJ, HARTOG M. THE EFFECT OF GROWTH HORMONE ON ALBUMIN TURNOVER IN MAN. Metabolism. 1965 Jan;14:67-74. doi: 10.1016/0026-0495(65)90082-x. PMID: 14252344.
Rahman MZ, Begum BA. Serum total protein, albumin and A/G ratio in different grades of protein energy malnutrition. Mymensingh Med J. 2005 Jan;14(1):38-40. PMID: 15695952.
Hausmann O, Warnatz K. Immunodeficiency in adults a practical guide for the allergist. Allergo J Int. 2014;23(7):261-268. doi: 10.1007/s40629-014-0030-4. Epub 2014 Nov 6. PMID: 26120536; PMCID: PMC4479546.
Walker HK, Hall WD, Hurst JW, editors. Chapter 101 - Serum Albumin and Globulin, Boston: Butterworths; 1990. [https://www.ncbi.nlm.nih.gov/books/NBK204/]
The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. A high albumin/globulin ratio could mean that your albumin levels are high, your globulin levels are low, or both. There are only a few reasons why the A/G ratio may be high and a high ratio is much less common compared to a low ratio.
- A high albumin/globulin ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias.
- A high A/G ratio can be a sign of disease in your liver, kidney, or intestines. It’s also linked to low thyroid activity and leukemia.
If your Albumin is high/elevated:
- Dehydration.
- High protein diet
- Insulin resistance
- Certain medications can increase albumin (ex. Prednisolone or Somatropin)
If your Globulin is low/decreased:
- Genetic defects increase chances of a disorder called immunodeficiency, which hinders the body’s ability to create antibodies (immunoglobulins).
- Acromegaly (= a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood) can be responsible for decreased globulon.
- Certain medication can decrease globulin (corticosteroids)
Note: Keep in mind that a low or high Albumin/Globulin ratio is usually due to an underlying condition (i.e. inflammation, liver disease, or interactions witht medications you take.) Please consult with your health care professional to address underlying causes to address your A/G ratio.
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A low A/G ratio could indicate your albumin levels are too low (hypoalbuminemia), or your globulin levels are too high. High globulin indicates inflammation and immune system activity.
Overall, a low A/G ratio result is associated with:
A 2010 research overview found low albumin levels were partially predictive of increased mortality rates for those with gastrointestinal, lung, and breast cancers among others.
Note: Keep in mind that a low or high Albumin/Globulin ratio is usually due to an underlying condition (i.e. inflammation, liver disease, or interactions witht medications you take.) Please consult with your health care professional to address underlying causes to address your A/G ratio.
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Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
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Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
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Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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