Uranium (Urine) on Vibrant’s Total Tox-Burden reflects recent exposure and is reported creatinine-corrected; values ≤ 0.04 µg/g are typical for the reference population, while higher results suggest increased intake in the past days–weeks. The most common sources are drinking water from uranium-rich aquifers (especially private wells), food or beverages made with such water, and inhalation of dust/fumes in mining, milling, ceramics, or similar workplaces; dermal uptake is minimal but hand-to-mouth transfer matters. Health concerns center on kidney (proximal tubule) toxicity; higher or prolonged exposures may also increase oxidative stress and genotoxic effects (chromosomal/DNA changes), though non-renal findings at low environmental levels are mixed. If elevated, reduce exposure at the source (test private wells; consider reverse osmosis or anion-exchange; improve workplace ventilation, housekeeping, and PPE), maintain adequate hydration, and avoid self-directed chelation. Many clinicians retest in ~2–3 weeks under similar collection conditions to confirm improvement, and you should seek medical care for kidney-related symptoms, during pregnancy, for children, or after significant inhalation/ingestion.

Uranium (U) is an abundant element on earth. Its widespread use in military and industry, including nuclear power, has increased human exposure. Uranium can be ingested or inhaled and is cleared in urine rapidly, although some will pool in bone and kidney tissues. Uranium toxicity in humans leads to renal damage. Lung cancer is commonly associated with inhaled uranium. Urine can be a sensitive specimen for uranium exposure, but assessment should be undertaken promptly. Intravenous sodium bicarbonate 1.4% has been used to treat uranium toxicity and inositol hexaphosphate has been used in animal studies.

Sources:

Largely limited to use as a nuclear fuel. Present naturally in air, water, food, and soil. The uranyl ion forms water-soluble compounds and is an important component in body fluids. Three different kinds are defined: natural, enriched, and depleted uranium(DU). The radiological and chemical propertiesof natural and DU have similar chemotoxicity, though natural is 60% more radiotoxic.

Nutrient Interactions:

U is reactive. It can combine with and affect the metabolism of lactate, citrate, pyruvate, carbonate,and phosphate, causing mitochondrialdamage. It replaces calciumin bone.

What is Uranium?

Uranium is a naturally occurring radioactive heavy metal found in soil, rocks, water, and certain foods. While small environmental exposures are common, elevated uranium levels in the body can be a health concern due to its chemical toxicity and potential for radiation exposure.

Uranium (U) is an abundant element on earth. Its widespread use in military and industry, including nuclear power, has increased human exposure. Uranium can be ingested or inhaled and is cleared in urine rapidly, although some will pool in bone and kidney tissues. Uranium toxicity in humans leads to renal damage. Lung cancer is commonly associated with inhaled uranium. Urine can be a sensitive specimen for uranium exposure, but assessment should be undertaken promptly. Intravenous sodium bicarbonate 1.4% has been used to treat uranium toxicity and inositol hexaphosphate has been used in animal studies.

→ Waste Product: Urea is a waste product formed in the liver from the breakdown of proteins.

→ Excretion Pathway: It is transported via the bloodstream to the kidneys, where it is filtered out and excreted in urine.

→ Health Indicator: Urea levels are measured to assess kidney function; high levels may indicate kidney dysfunction.

→ Protein Metabolism: It helps remove excess nitrogen from the body, a byproduct of protein metabolism.

→ CMP Component: Urea (or BUN) is a key marker on a Comprehensive Metabolic Panel (CMP) used to monitor overall metabolic and renal health.

Urea is a nontoxic byproduct of nitrogen (ammonia) detoxification. It is formed in the liver via the urea cycle and is the end product of protein metabolism. It is essentially a waste product with no physiological function.

Urea is a nontoxic byproduct of nitrogen (ammonia) detoxification. It is formed in the liver via the urea cycle and is the end product of protein metabolism. It is essentially a waste product with no physiological function.

Urea is a nontoxic byproduct of nitrogen (ammonia) detoxification. It is formed in the liver via the urea cycle and is the end product of protein metabolism. It is essentially a waste product with no physiological function.

Urea is the final excretory product of nitrogen (protein) metabolism in the body.

Urea is a nontoxic byproduct of nitrogen (ammonia) detoxification. It is formed in the liver via the urea cycle and is the end product of protein metabolism. It is essentially a waste product with no physiological function.

Urea is the principal nitrogenous waste product of metabolism and is generated from protein breakdown.

Likely to form uric acid stones; some people who have increased uric acid also have gout

Uric acid is a natural byproduct formed during the breakdown of our body’s cells and the food that we eat. Excess uric acid can be caused by either an overproduction of uric acid or inefficient removal of it from the blood. The most common affliction associated with excess uric acid is gout, a painful form of arthritis.

May indicate oxidative stress and elevated levels are associated with cardiovascular disease and diabetes. May be elevated due to gout, kidney dysfunction, excess alcohol intake, starvation, extreme calorie restriction, liver dysfunction, hemolytic anemia, excess fructose consumption, fungal infection, ketogenic diet, supplemental niacin, high protein diet, prolonged fasting, supplemental vitamin B3, excess acidity. May be decreased due to nutrient deficiencies (molybdenum, zinc, iron), oxidative stress, low purine intake (vegetarian or vegan), excess alkalinity.