NutriPATH

Advanced Dried Urine Hormone Profile The Advanced Dried Urine Hormone Profile provides a comprehensive evaluation of key hormone levels and their metabolites, offering deeper insights into hormonal balance and function. This test assesses a range of sex hormones, adrenal hormones, and their metabolites, helping to identify imbalances that may contribute to various symptoms and health conditions. Hormone fluctuations are a natural part of life, especially in women, where levels shift throughout the menstrual cycle and different life stages. However, disruptions in this balance can lead to issues such as PMS, menopause, infertility, and complex conditions like PCOS and endometriosis. By analyzing dried urine samples, this test delivers a detailed view of hormone metabolism, guiding targeted treatment strategies for hormonal health. Conditions and Symptoms Associated with Hormonal Imbalances: PMS Menopause Fertility challenges Adrenal dysfunction and stress Endometriosis PCOS Uterine fibroids Fibrocystic breasts Hormone-related cancers Osteoporosis Fatigue Insomnia This test is ideal for individuals experiencing symptoms of hormonal imbalance or those seeking a proactive approach to hormonal health. It provides actionable insights for personalized treatment plans, whether addressing reproductive health, adrenal function, or overall hormone metabolism.

CDSA Level 1 – Comprehensive Digestive Stool Analysis (NutriPATH) NutriPATH offers a broad range of gastrointestinal test panels designed to give healthcare practitioners the flexibility to choose the most appropriate analyses for each patient’s needs. The CDSA Level 1 test provides a detailed assessment of the gut’s microbiological environment. It includes: Macroscopic and microscopic evaluation Bacteriology Mycology (yeast detection) Parasitology This test helps identify imbalanced colonizing organisms and potential pathogens, while also measuring levels of beneficial flora. It is a valuable tool for detecting gut infections or confirming/excluding dysbiosis. The CDSA can support earlier, more targeted interventions, improve treatment precision, and help reduce the risk of relapse—especially in patients with chronic or recurrent gastrointestinal symptoms. It also supports clinical decision-making when evaluating the necessity of more invasive procedures such as colonoscopy. The Level 1 assessment is a cost-effective option and can be particularly useful in cases where infection or microbiome imbalance is suspected. For enhanced parasite detection, it is recommended to add the DNA Multiplex PCR (Test Code 2002) to any CDSA level.

The Complete Microbiome Mapping Test was designed to assess a patient’s microbiome from a single stool sample, with particular attention to microbes that cause disease or that disrupt normal microbial balance and contribute to perturbations in the GI flora and contribute to illness. The panel is a comprehensive collection of microbial targets as well as immune and digestive markers. It screens for pathogenic bacteria, commensal bacteria, opportunistic pathogens, fungi, viruses, and parasites. Common Conditions: IBS/IBD Abdominal cramps or pain leaky gut symptoms SIBO Allergies Weakness Diarrhoea Bloating Fatigue

The Cortisol Awakening Response (CAR) test is a non-invasive saliva test that serves as a reliable marker of stress response and a critical tool for revealing adrenal imbalances. Lifestyle, physical and psychological stresses put constant demands on the adrenal glands. If they become depleted adrenal fatigue or insufficiency may be experienced. The Cortisol Awakening Response (CAR) test is a unique assessment measuring the predictable rise and fall in cortisol within the first hour of awakening. The test is essential in evaluating the overall function of the HPA axis. In this particular test we measure cortisol immediately on rising, 30 minutes post waking, 60 minutes post waking, 12:00 (noon), 4:00pm and 8:00pm. The CAR test allows your physician to determine how healthy your HPA axis is which useful in assessing the HPA-axis. The CAR test is an appropriate tool in practice for most of your patients as it provides an easy assessment of their ability to deal with stressors and is also reflective of how well they have dealt with stressors in the past. Analytes: - Cortisol (on waking) - Cortisol +30 mins - Cortisol +60mins - Cortisol 12:00noon - Cortisol 4:00pm - Cortisol 8:00pm - DHEAs CORTISOL AWAKENING RESPONSE: The cortisol awakening response (CAR) test is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. In a normal individual without significant stressors, cortisol is highest in the morning shortly after awakening, rises by up to 60% roughly 30 minutes after awakening, then steadily drops throughout the day, reaching the lowest level during sleep in the very early morning about 2 am. A loss of the expected curve with its characteristic morning peak and steady decline towards evening may suggest HPA axis dysfunction. CAR RISE RESPONSE WITHIN NORMAL RANGE: The rise in Cortisol from waking to 30 minutes post-waking is within normal range. This indicates normal Cortisol production/metabolism. CAR DECLINE RESPONSE WITHIN NORMAL RANGE: The decline in Cortisol from waking to 60 minutes post-waking is within normal range. This is consistent with normal Cortisol production/metabolism. LOW/LOW NORMAL MIDDAY CORTISOL LEVEL: Midday Cortisol level is below mean range and suggestive of adrenal insufficiency. This suggests suboptimal adrenal functioning, and if accompanied by low evening cortisol and low DHEA, suspect adrenal fatigue. Suggest supplementation with DHEA and standard adrenal support. LOW/LOW NORMAL LATE AFTERNOON: Late afternoon cortisol level insufficiency. This suggests by low evening cortisol and low DHEA, suspect adrenal fatigue. Suggest supplementation with DHEA and standard adrenal support. EVENING CORTISOL LEVEL WITHIN RANGE: Saliva evening cortisol level is normal and within range. References: Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002 Oct;53(4):865-71. doi: 10.1016/s0022-3999(02)00429-4. PMID: 12377295. [L] Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009 Apr;72(1):67-73. doi: 10.1016/j.ijpsycho.2008.03.014. Epub 2008 Sep 30. PMID: 18854200. [L] Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L. The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev. 2010 Sep;35(1):97-103. doi: 10.1016/j.neubiorev.2009.12.011. Epub 2009 Dec 22. PMID: 20026350. [L] Hackett RA, Kivimäki M, Kumari M, Steptoe A. Diurnal Cortisol Patterns, Future Diabetes, and Impaired Glucose Metabolism in the Whitehall II Cohort Study. J Clin Endocrinol Metab. 2016 Feb;101(2):619-25. doi: 10.1210/jc.2015-2853. Epub 2015 Dec 8. PMID: 26647151; PMCID: PMC4880118. [L] Hammer F, Deutschbein T, Marx A, Güder G, Michalski R, Ertl G, Allolio B, Angermann CE, Störk S, Fassnacht M. High evening salivary cortisol is an independent predictor of increased mortality risk in patients with systolic heart failure. Int J Cardiol. 2016 Jan 15;203:69-73. doi: 10.1016/j.ijcard.2015.10.084. Epub 2015 Oct 20. PMID: 26492313. [L]

Folate is a water soluble B vitamin (B9), which humans cannot synthesise and is thus a dietary requirement. The primary function of folate is the transfer of methyl and formyl groups. It is essential for cell growth and reproduction, the formation of certain amino acids (methionine, serine, glycine and histidine), the breakdown of proteins (e.g. homocysteine), the formation of DNA and RNA, red blood cell maturation and serotonin, noradrenaline (norepinephrine) and dopamine formation. Active and Inactive Forms of Folate Dihydrofolate (DHF) is the dietary form of folate, whilst folic acid is the synthetic form of folate used in supplements and to fortify the food supply. These forms of folate are not biologically active; they must undergo enzymatic transformation to L-methylfolate in order to be used by cells. L-methylfolate, unlike the other folates, is able to cross the blood-brain barrier for use in the CNS. The conversion of dihydrofolate (DHF) and folic acid to L-methylfolate occurs through a three or four step process: • Folic acid is converted to DHF by the dihydrofolate reductase enzyme (DHFR) • DHF is then converted to tetrahydrofolate (THF) • THF is converted to 5,10-methyleneTHF • 5,10-methyleneTHF is converted to L-methylfolate by the methyltetrahydrofolate reductase enzyme (MTHFR). L-MethylFolate Deficiencies: For many people, their DHF from the diet leads to adequate L-methylfolate levels, however, malabsorption, digestive and liver disease, as well as certain genetic enzyme polymorphisms, can result in an impaired ability to activate folic acid. This L-methylfolate deficiency results in symptoms and conditions including mental health disorders, cardiovascular disease, increased adiposity, reduced lean body mass, birth defects and an increased risk for certain cancers. Folate metabolism is required for optimal methylation. Methylation is a major pathway to focus on in understanding autoimmune and neurological diseases such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety and autism spectrum disorders. Methylation is responsible for making, maintaining and repairing DNA. The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions: detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation, synthesising neurotransmitters, homocysteine metabolism, protein methylation, phase 2 liver detoxification and supporting immune function. Inadequate methylation capacity can lead to birth defects, depression, cognitive decline and cancer. Impaired methylation has even been associated with autism. Support of methylation markers has been associated with rapid return of speech, improvement of behaviour in ADD and ADHD spectrums. Conditions associated with impaired folate and methylation defects: Allergies, Diabetes, Autism, High folate supplementation, Cancer, Infertility, Pre-conception care, Chronic Fatigue Syndrome, Mental health disorders, Cognitive decline, Estrogen dominance, Cardiovascular disease, Schizophrenia. Analytes: 5-methyl tetrahydrofolate (5MTHF) Active Vitamin B12 Folinic acid Homocysteine Serum Folate Tetrahydrofolate (THF)

Hair Metal and Mineral Analysis: Understanding Nutrient and Toxic Metal Levels Hair metal and mineral analysis evaluates the nutrient and toxic metal content in hair, offering insights into the body’s mineral status and exposure to harmful substances. Hair serves as an excellent medium for such analysis because it reflects both external environmental exposure and internal absorption through the bloodstream. Over time, minerals and metals accumulate in hair, providing a stable record of metabolic and cellular activity. This test can measure a wide range of metals and minerals in a single sample, giving valuable information about nutrient metabolism and cellular function. Since minerals are essential catalysts for every physiological process in the body, their levels in hair can reveal imbalances that impact overall health. The structure of hair remains unchanged after growth, meaning mineral levels in each section remain fixed, accurately reflecting accumulation over the hair growth period, typically 1–3 months. Toxic heavy metals, absorbed from pollution, chemicals, and environmental poisons, pose a growing threat to health. These metals accumulate in body tissues and can cause significant developmental, neurological, and systemic damage. Heavy metal toxicity has been linked to a wide range of health issues, including those affecting the cardiovascular, endocrine, immune, musculoskeletal, skin, and nervous systems. Hair analysis provides a non-invasive method to identify such exposures and guide interventions for better health.

Methylation is a process where certain nutrients called ‘methyl donors’ are added to specific elements of DNA, our gene markers and proteins that keep them physiologically active. Methylation is a major pathway to focus on in understanding autoimmune and neurological diseases such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety and autism spectrum disorders. Methylation is responsible for making, maintaining and repairing DNA. The methylation cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions: detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation, synthesising neurotransmitters, homocysteine metabolism, protein methylation, phase 2 liver detoxification and supporting immune function. Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer. Impaired methylation has even been associated with autism. Support of methylation markers has been associated with rapid return of speech, improvement of behaviour in ADD and ADHD spectrums. Methionine is an amino acid necessary for utilisation of methyl groups from the folate cycle and balance homocysteine levels. Methionine synthase (MTR) requires vitamin B12 and an enzyme, methionine synthase reductase, which is produced from the MTRR gene. Homocysteine, a sulphur-containing amino acid, is a metabolite of the essential amino acid methionine, and exists at a critical biochemical intersection in the methionine cycle between (Sadenosylmethionine), the indispensable ubiquitous methyl donor, and vitamins B12 and folic acid. High blood levels of homocysteine signal a breakdown in this vital process, resulting in far-reaching biochemical consequences. The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions: detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation, synthesising neurotransmitters, homocysteine metabolism, protein methylation, phase 2 liver detoxification and supporting immune function. Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer. Impaired methylation has even been associated with autism. Support of methylation markers has been associated with rapid return of speech, improvement of behaviour in ADD and ADHD spectrums. Conditions associated with impaired methionine and methylation defects: Allergies, Diabetes, Autism, High folate supplementation, Cancer, Infertility, Pre-conception care, Chronic Fatigue Syndrome, Mental health disorders, Cognitive decline, Estrogen dominance, Cardiovascular disease, Schizophrenia. Significant markers of methionine metabolism assessment: SAMe (S-adenosylmethionine) - a synthetic form of a compound formed naturally in the body from the essential amino acid methionine and adenosine triphosphate (ATP), the energyproducing compound found in all cells in the body. SAH (S-adenosyl Homocysteine) - amino acid derivative and modulator of the activated methyl cycle and cysteine biosynthesis and product of SAMe-dependant methylation of biological molecules, including DNA, RNA, histones and other proteins. Vitamin B12 - essential for recycling homocysteine and the formation of methyl donors involved in cardiovascular function, sleep, blood cell formation, and nerve function. Folate - a substrate and vitamin B12 is a coenzyme for the formation of MTHF that depends on the regeneration of THF, the parent compound in the homocysteine-to-methionine conversion. Homocysteine - an amino acid associated with atherosclerosis that can become elevated when there is need for folate, vitamin B6 and/or vitamin B12. Methionine - an amino acid necessary for utilisation of methyl-groups from the folate cycle and balance homocysteine levels.

myDNA Comprehensive Health Report The myDNA Comprehensive Health Report is an advanced DNA methylation and genetic testing panel designed to give a deep, personalized understanding of your genetic blueprint. By analyzing key genetic markers, this test helps uncover how your DNA influences digestion, hormones, energy, stress, inflammation, detoxification, and overall health. Unlike standard health tests, this report goes beyond surface-level results, providing actionable insights for both patients and practitioners. With a focus on preventative health and wellness, it identifies genetic strengths and potential weaknesses, guiding tailored nutrition, lifestyle, and treatment strategies. What the test measures The report examines 92 genes and 113 SNPs (single nucleotide polymorphisms) across major areas of health, including: Digestion – insights into nutrient absorption, gut health, and food sensitivities. Energy – how your body converts food into usable energy. Hormones – genetic markers affecting hormone balance and metabolism. Stress & Cognitive Performance – resilience, mood regulation, and focus. Inflammation – predisposition to chronic inflammation and recovery speed. Athletic Performance – genetic traits linked to strength, endurance, and recovery. DNA Protection & Repair – markers influencing healthy aging and cellular repair. Detoxification – genetic capacity to clear toxins and support liver function. Each category comes with a genetic strengths and weaknesses summary, making it easy to see where your body may be performing well and where extra support may be needed. Key Features Personalized shopping list – tailored food and nutrient recommendations to support your genetic profile. Suggested follow-up blood tests – helping practitioners validate findings and build a more complete health picture. Holistic guidance – empowering long-term health, wellness, and prevention strategies. Who is this test for? The myDNA Comprehensive Health Report is ideal for individuals who want to: Take a proactive approach to long-term health and wellness. Understand their genetic risk factors for common health concerns. Optimize diet, fitness, stress resilience, and lifestyle choices. Work with their practitioner to create a personalized, DNA-driven health plan.

Neurotransmitter-Intermediate Profile – Functional Testing for Mood and Cognitive Health Effectively assessing and treating mood disorders requires more than just observation—it demands objective clinical data. Traditional care often relies on a trial-and-error approach to psychiatric medications, guided by patient self-reports and clinician evaluations. While this can work for some, it may also lead to delays in finding the right treatment and increases the risk of side effects or worsening symptoms during interim failures. The Neurotransmitter-Intermediate Profile provides an evidence-based alternative by offering a four-point urine analysis that measures nine key neurotransmitters involved in emotional, cognitive, and metabolic regulation. These neurotransmitters influence a wide range of physiological and psychological functions, including mood, hormone balance, sleep, stress response, pain perception, appetite, memory, and focus. Neurotransmitters Assessed: Serotonin GABA Dopamine Noradrenaline (Norepinephrine) Adrenaline (Epinephrine) Glutamate Phenylethylamine (PEA) Glycine Histamine Neurotransmitter Ratios for clinical insight Clinical Relevance Each report includes a correlation analysis, prepared by NutriPATH’s clinical team, aligning the patient's reported symptoms with their specific neurotransmitter levels. This gives practitioners a powerful tool to: Identify biochemical imbalances contributing to mood disorders Tailor personalized treatment plans Monitor therapeutic effectiveness objectively over time Common Conditions Supported: Mental & Emotional Health: Anxiety and depression Mood swings Aggression Poor motivation, concentration, and memory Other Related Health Issues: Hormonal imbalances Thyroid dysfunction Gut-brain axis disorders (e.g., GIT issues) ADHD or hyperactivity Test Methodology Test Type: Four-point urine collection Technology: LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry) Turnaround Time: Fast, accurate results with detailed interpretation By objectively measuring neurotransmitter levels, the Neurotransmitter-Intermediate Profile offers healthcare practitioners a clinical edge—helping them move beyond subjective assessments to develop truly personalized, data-driven treatment strategies.

NutriStat: The Ultimate Nutritional and Metabolic Health Test Panel The NutriStat Profile is a cutting-edge diagnostic test designed to optimize your nutritional and metabolic health through a simple blood and urine sample. This comprehensive test evaluates a wide range of biomarkers, offering valuable insights into areas such as metabolic health, thyroid function, cardiovascular health, and hormonal balance. By identifying functional nutritional needs, the NutriStat profile empowers individuals to take proactive steps toward better health and disease prevention. What Does the NutriStat Profile Assess? The NutriStat Profile analyzes key biochemical markers to provide a detailed overview of your body’s nutritional and functional status. It covers: 1. Mineral and Metal Status Assesses levels of essential minerals such as magnesium, zinc, and selenium. Screens for heavy metal exposure, including lead, mercury, and cadmium. 2. Essential Fatty Acids Evaluates omega-3 and omega-6 balance, crucial for inflammation control, brain health, and cardiovascular function. 3. Amino Acids Measures essential and nonessential amino acids, identifying imbalances affecting muscle health, immune function, and neurotransmitter production. 4. Organic Acids Provides insights into energy production, detoxification, and gut microbial balance. 5. Thyroid Health Examines markers related to thyroid function, which play a critical role in metabolism, energy levels, and hormonal health. 6. Cardiovascular Health Evaluates biomarkers such as lipid profiles, oxidative stress indicators, and fatty acid balance to support heart health. 7. Hormonal Health Analyzes markers associated with reproductive health, hormone balance, and fertility. Who Should Consider the NutriStat Profile? The NutriStat Profile is ideal for individuals with a variety of health concerns or those seeking to optimize their overall wellness. It is especially beneficial for: Cardiovascular Disease: Identifies nutrient and metabolic factors influencing heart health. Malnutrition, Malabsorption, or Maldigestion: Reveals underlying issues affecting nutrient intake and absorption. Obesity and Weight Management: Supports personalized strategies for metabolic health and weight control. Insulin Resistance and Type 2 Diabetes: Provides insights into glucose regulation and metabolic efficiency. Athletic Performance: Helps optimize nutrition for endurance, recovery, and performance. Fertility and Hormone Health: Evaluates factors affecting reproductive health and hormone balance. Heavy Metal Toxicity and Mineral Deficiency: Detects toxic exposures while identifying key mineral imbalances. Why Choose the NutriStat Profile? The NutriStat Profile goes beyond standard testing by integrating a diverse range of biomarkers, enabling a holistic understanding of your health. Key benefits include: Comprehensive Biomarker Analysis: Measures a broad spectrum of nutrients, metabolic byproducts, and functional health indicators. Personalized Recommendations: Delivers actionable insights to guide dietary, supplement, and lifestyle interventions. Targeted Health Insights: Helps uncover the root causes of health concerns and supports evidence-based decision-making. Convenience and Accuracy: Combines blood and urine testing for a complete picture of nutritional health. Common Conditions Supported by the NutriStat Profile This versatile test is highly applicable for individuals with diverse health conditions, including: Cardiovascular disease Malnutrition, malabsorption, or digestive issues Obesity and weight management challenges Insulin resistance and Type 2 diabetes Hormonal imbalances and fertility concerns Heavy metal toxicity Athletes seeking peak performance How Does the NutriStat Profile Work? Using a simple blood and urine sample, the NutriStat Profile evaluates multiple biomarkers across key health domains. By combining advanced testing methods, this profile identifies imbalances that may not be evident through standard tests, empowering individuals to take control of their health. Achieve Optimal Wellness with NutriStat The NutriStat Profile is more than just a test—it’s a pathway to better health. Whether you’re addressing specific health concerns or seeking to enhance your overall wellness, this comprehensive assessment provides the tools needed to make informed, proactive health decisions. Take the first step toward better health today by consulting your healthcare provider about the NutriStat Profile.

The Organic Acids Metabolomic Profile is a nutritional test providing insights into organic acids and a view into the body’s cellular metabolic processes. Additionally, children’s reference ranges are designed to provide more accurate paediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. The Organic Acids Metabolomic profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining: - Functional vitamin and mineral status - Amino acid insufficiencies like carnitine and NAC - Oxidative damage and antioxidant need - Phase I & Phase II detoxification capacity - Functional B-complex vitamin need - Neurotransmitter metabolites - Mitochondrial energy production - Methylation sufficiency - Lipoic acid and CoQ10 status - Markers for bacterial and yeast overgrowth - Oxalate markers - Nutritional markers