Optimal Result: 168 - 465 mmol/g creatinine.

Urea is the principal nitrogenous waste product of metabolism and is generated from protein breakdown. It is eliminated from the body almost exclusively by the kidneys in urine.

In a series of five enzymatically controlled reactions, known collectively as the “urea cycle”, toxic ammonia resulting from protein breakdown is converted to non-toxic urea.

In addition to ammonia and the five ”urea cycle” enzymes, endogenous production of urea requires the presence of bicarbonate, aspartate and energy input in the form of adenosine triphosphate (ATP).

Carbon dioxide (CO2) is a secondary product of the urea cycle. Almost all of this urea production occurs in the cells of the liver (hepatocytes); the only other source is the cells of the kidneys.

As might be expected, the rate of urea production is influenced by protein content of diet; low-protein diet is associated with reduced urea production and high-protein diet is associated with increased urea production.

Starvation is, perhaps counterintuitively, associated with increased urea production but this is explained by the increased protein released from muscle tissue breakdown (autolysis) that occurs during starvation to provide an energy source.

A small amount (<10 %) of urea is eliminated via sweat and the gut, but most of the urea produced in the liver is transported in blood to the kidneys where it is eliminated from the body in urine.

What does it mean if your Urea (Urine) result is too low?

Low levels of urea in the urine may suggest:

- malnutrition
- too little protein in the diet
- kidney disease

What does it mean if your Urea (Urine) result is too high?

High levels of urea in the urine may suggest:

- too much protein in the diet
- excessive protein breakdown in the body

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan

  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan

  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals

  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: