Sources:
Widespread use in military and industry as well as nuclear power.
Symptoms:
- Renal damage
- Lung cancer
Treatment:
- Avoidance
- IV sodium bicarbonate
- Inositol hexaphosphate (animal studies)
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Uranium (U) is an abundant element on earth. Its widespread use in military and industry, including nuclear power, has increased human exposure. Uranium can be ingested or inhaled and is cleared in urine rapidly, although some will pool in bone and kidney tissues. Uranium toxicity in humans leads to renal damage. Lung cancer is commonly associated with inhaled uranium. Urine can be a sensitive specimen for uranium exposure, but assessment should be undertaken promptly. Intravenous sodium bicarbonate 1.4% has been used to treat uranium toxicity and inositol hexaphosphate has been used in animal studies.
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Renal excretion via urine accounts for most uranium (U) that is excreted from the body. Uranium is considered mildly toxic for two reasons: 1) low-level radioactivity and 2) moderate biochemical toxicity.
Uranium is more common than mercury, silver or cadmium in the earth's rock strata, and may be present, at low levels, in ground (drinking) water. Most commercial use of U is for nuclear fuel, but it may be present in ceramics or colored glass, especially ancient or antique, yellow-colored glassware.
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The treatment for elevated uranium levels in urine largely depends on the severity and cause of the exposure.
Here are some potential approaches:
Increasing Urinary Output: Increasing fluid intake to increase urinary output is commonly recommended for cases of exposure to uranium. This helps to flush the system and promote the excretion of uranium through the urine.
No Clear Evidence of Kidney Injury: It is worth noting that studies of persons with chronic exposure to soluble uranium salts, particularly in drinking water, have not shown kidney injury associated with elevated urinary uranium levels. This suggests that the body may have mechanisms to cope with certain levels of exposure without apparent harm, though this doesn't negate the need for medical attention if exposure is suspected.
Use of Sodium Bicarbonate: Research indicates that sodium bicarbonate may help protect against acute nephrotoxicity (kidney damage) induced by uranium. It is thought to work by increasing the blood level of bicarbonate ions, which in turn increases the stable uranyl ion complex in the blood and urine, potentially reducing harm.
Monitoring Kidney Function: Elevated uranium in urine can impact kidney function, as indicated by a greater urine albumin-creatinine ratio in those with detectable urine uranium concentrations. Monitoring and assessing renal function can be an important part of managing uranium exposure.
Controversy Over Chelation: The use of chelation therapy, which involves administering agents to bind the heavy metals and remove them from the body, is controversial and not commonly practiced in the United States for cases of uranium exposure. There are no reported cases of chelation being used to treat uranium overexposure in the Western world.
It is essential for anyone with elevated uranium levels to seek medical advice for a tailored treatment plan, as the appropriate approach can vary widely based on individual circumstances. Medical professionals can provide the best guidance on managing and mitigating the effects of uranium exposure. Please do not start a treatment plan without consulting a medical professional.
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