Orotate is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotate is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Orotic Acid is an organic acid which serves as an intermediate in nucleotide synthesis and is linked to arginine metabolism as a urea cycle marker for nitrogen balance.

It is formed from aspartic acid and carbamoyl phosphate. Carbamoyl phosphate plays an important role in the body because it brings nitrogen into the urea cycle for detoxification and disposal. Carbamoyl phosphate enters the urea cycle to react with ornithine to form citrulline. When ammonia levels significantly increase or the liver’s capacity for detoxifying ammonia into urea decreases, carbamoyl phosphate leaves the mitochondria and instead enters the pyrimidine pathway. This stimulates orotic acid biosynthesis and subsequent urinary excretion. Orotic acid can also be found in the diet. The richest dietary sources include cow’s milk and dairy products.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.

Oscillospira is a common yet rarely cultivated gut bacterial genus. Recently human gut microbiota studies have demonstrated its underlying significance for host health.

Osmolality measures the concentration of dissolved particles in a fluid, such as blood, urine, or stool, providing insights into the body’s water balance and kidney function. The osmolality test evaluates the concentration of key substances like sodium, potassium, chloride, glucose, and urea. By assessing these levels, the test helps detect imbalances that may affect hydration, kidney health, and electrolyte status.

In blood osmolality, sodium plays a central role as the main electrolyte, working alongside potassium, chloride, and bicarbonate (CO2) to maintain electrical neutrality and acid-base balance in the body. Sodium intake through diet is typically regulated by the kidneys, which either conserve or excrete sodium to keep blood levels stable.

Osmolality (U), also known as urine osmolality, measures the concentration of dissolved particles, such as electrolytes, urea, and glucose, in urine. It provides insight into how well the kidneys are functioning and maintaining the body's fluid balance. By measuring urine osmolality, doctors can evaluate how the kidneys are responding to different conditions, such as dehydration or excessive fluid intake. This test is usually done by analyzing a urine sample, which helps determine the concentration of particles and offers important information about kidney health and the body's ability to regulate water and electrolytes.

Function:

A star-shaped cell, an osteocyte is an abundant cell found in compact bone. Cytoplasmic extensions, which occupy canals called canaliculi, network osteocytes. Canaliculi are used by osteocytes for the exchange of nutrients and waste through gap junctions. Osteocytes are actively involved in the routine turnover of bony matrix, through various mechanisms. Through a mechanism called osteocytic osteolysis, osteocytes can destroy bone.

Antibodies Appear:

Osteoclastogenesis [4]

Osteopenia [3]

Osteoporosis [3]

Known Cross-Reactions:

Phosphatase I, [1] gliadin [5]

Clinical Significance: