Other names: VLDL Particle Size
Optimal Result:
0 - 46.6 nm.
Special proteins, apoproteins, play an important role in moving lipoproteins around the body and facilitating their interactions with other cells. The most important of these are the apoB class, residing on VLDL, IDL, and LDL particles, and the apoA-I class, residing for the most part on the HDL particles.
VLDL are one of the major triglyceride-rich lipoproteins. They carry endogenous, hepatically synthesized triglycerides, largely derived from dietary carbohydrate or from plasma NEFA (=Non-Esterified Fatty Acids), and are of a large size (30–60 nm diameter).
Each VLDL particle has a single molecule of a larger apoB form, apoB100, with other apolipoproteins (apoE and apoCs) being acquired in plasma from HDL.
The levels of VLDL are not the only thing that matters. The size and chemical makeup of VLDL particles also contribute to health risks.
VLDL size is dependent on the triglyceride content, with large buoyant triglyceride-enriched VLDL being formed at times of triglyceride excess.
These large VLDL may be a poorer substrate for the usual path of metabolism involving apoCII-dependent activation of LPL and apoCII-LPL binding similar to that seen with chylomicrons, and thus have a longer residency time in the blood. As triglyceride is hydrolyzed, VLDL particles shrink with loss of surface components to HDL and subsequent catabolism to LDL via IDL. This process is less efficient in the presence of high triglyceride levels and large buoyant VLDL. A longer plasma residency time allows a greater exchange of triglyceride from VLDL into LDL and HDL with reverse exchange of cholesterol ester, mediated by cholesterol ester transfer protein (CETP). This produces cholesterol-enriched VLDL remnants that are less readily metabolized to LDL and can be removed by alternative, but potentially atherogenic, pathways. Additionally, this process produces triglyceride-enriched LDL that shrink as some triglyceride is hydrolyzed in the liver by another endothelial enzyme, hepatic lipase, producing small, dense LDL.
References:
J.P.D. Reckless, J.M. Lawrence, HYPERLIPIDEMIA (HYPERLIPIDAEMIA), Editor(s): Benjamin Caballero, Encyclopedia of Food Sciences and Nutrition (Second Edition), Academic Press, 2003, Pages 3183-3192, ISBN 9780122270550, https://doi.org/10.1016/B0-12-227055-X/00613-1. (https://www.sciencedirect.com/science/article/pii/B012227055X006131)
Lucero D, Zago V, López GH, Cacciagiú L, López GI, Wikinski R, Nakajima K, Schreier L. Predominance of large VLDL particles in metabolic syndrome, detected by size exclusion liquid chromatography. Clin Biochem. 2012 Mar;45(4-5):293-7. doi: 10.1016/j.clinbiochem.2011.12.013. Epub 2012 Jan 3. PMID: 22245548.
McEneny J, McPherson P, Spence M, Bradley U, Blair S, McKinley M, Young I, Hunter S. Does a diet high or low in fat influence the oxidation potential of VLDL, LDL and HDL subfractions? Nutr Metab Cardiovasc Dis. 2013 Jul;23(7):612-8. doi: 10.1016/j.numecd.2011.12.007. Epub 2012 Mar 8. PMID: 22405535.
Sacks FM. The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia. Curr Opin Lipidol. 2015 Feb;26(1):56-63. doi: 10.1097/MOL.0000000000000146. PMID: 25551803; PMCID: PMC4371603.
Notø AT, Mathiesen EB, Brox J, Björkegren J, Hansen JB. The ApoC-I content of VLDL particles is associated with plaque size in persons with carotid atherosclerosis. Lipids. 2008 Jul;43(7):673-9. doi: 10.1007/s11745-008-3193-2. Epub 2008 May 29. PMID: 18509687.
Metabolic syndrome is associated with large VLDL [L]. Metabolic syndrome is the medical term for a combination of diabetes, high blood pressure (hypertension) and obesity. It puts you at greater risk of getting coronary heart disease, stroke and other conditions that affect the blood vessels.
The key aspect is to collaborate with your doctor to identify the underlying cause of your elevated VLDL-C levels and address any associated conditions. Depending on your medical history and test results, your doctor may prescribe cholesterol-lowering medication [L].
To effectively lower your VLDL cholesterol, it is crucial to focus on reducing your triglyceride levels. This can be achieved by implementing healthy lifestyle modifications, such as losing excess weight and engaging in regular exercise. Additionally, it is advised to limit the consumption of sugary foods and alcohol, as these substances have a significant impact on triglyceride levels [L].
By following these lifestyle adjustments and working closely with your doctor, you can effectively manage and lower your VLDL cholesterol levels, mitigating the associated risks of heart disease and other related conditions [L].
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Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
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Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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Export Your Complete Lab History
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
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Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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