HDLs comprise a family of heterogeneous particles that vary by size, density, composition, and functionality. Two distinct HDL subfractions, large buoyant HDL2 and small dense HDL3, might exert differential effects on atherosclerosis and display a promising role in CAD risk prediction.
HDL-2 is part of the larger HDL cholesterol family, which is responsible for removing excess cholesterol from the body and transporting it to the liver. HDL-2 is formed when HDL particles in the blood interact with enzymes and acquire more cholesterol.
The large HDL2 is superior to small HDL3 in the assessment of of coronary artery disease risk.
References:
Wu X, He Z, Sun R, Xie X, Chen Q, Wang J, Bao J, Huang J, Jiang Y, Zhang Y, Wang J. Large HDL2 combined with inflammatory factors as superior predictors for coronary artery disease than small HDL3. Ann Transl Med. 2021 Apr;9(8):672. doi: 10.21037/atm-21-948. PMID: 33987370; PMCID: PMC8106016.
HDL2 is often thought to be the “protective” form of HDL, and has been shown to have an inverse relationship with the risk of coronary artery disease.
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HDL2 is often thought to be the “protective” form of HDL, and has been shown to have an inverse relationship with the risk of coronary artery disease.
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Apolipoprotein A-1, Apolipoprotein B, Apolipoprotein B/A1 Ratio, Apoprotein B100 (ApoB 100), HDL Large, HDL-2, HDL-3, HDL-P, LDL Medium, LDL Particle Number, LDL Pattern, LDL Peak Size, LDL Size, LDL Small, LDL-P, LDL1 Pattern A, LDL2 Pattern A, LDL3 Pattern B, LDL4 Pattern B, Lipoprotein(a) / Lp(a), LP PLA2 ACTIVITY, LP-IR Score, Small LDL-P, VLDL Cholesterol Cal, VLDL-3
