High-density lipoproteins (HDL) comprise particles of different size, density and composition and their vasoprotective functions may differ.
In the cardiovascular field, both HDL cholesterol (HDL-C) concentration and HDL particle size are independently associated with cardiovascular risk. In particular, large HDL particles appear to be protective in coronary artery disease. HDL particle (HDL-P) number has been proposed as improved inverse predictor of CVD compared to plasma HDL-C.
HDL-Cholesterol (HDL-C) has been repeatedly inversely related to cardiovascular risk in all epidemiological studies. However, pharmacological trials aimed at increasing HDL-C have failed to demonstrate a beneficial effect on clinical outcomes. Also, some genetic variants associated to increased HDL-C have not been found associated to a decreased cardiovascular risk but those HDL randomization studies are questionable because they disregarded the complexity of lipoprotein metabolism by excluding from their analyses important genes that not exclusively regulate HDL-C levels but also those of other lipoproteins. This has led to the concept that a single measurement of HDL-C does not necessarily reflect the functional properties of HDL particles and their effects against atherosclerosis. Indeed, HDL particles are heterogeneous in size and biochemical composition, and HDL subpopulations might have different functional properties. Numerous recent studies have shown that the atheroprotective properties of HDL are supported by small and medium-sized HDL particles, which were inversely related to cardiovascular risk in various clinical settings.
Larger and smaller HDL particles have been reported to relate differently to lipid transport, as well as to anti-inflammatory and antioxidative functions.
A note on postmenopausal women and HDL-C/Particles:
Elevated HDL-C may not always be cardioprotective in postmenopausal women. The cardioprotective capacity of large HDL-P may adversely compromise close to menopause supporting the importance of assessing how the menopause transition might impact HDL quality and related cardiovascular disease risk later in life.
References:
Parra ES, Panzoldo NB, Zago VH, Scherrer DZ, Alexandre F, Bakkarat J, Nunes VS, Nakandakare ER, Quintão EC, Nadruz W Jr, de Faria EC, Sposito AC. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. PLoS One. 2014 Dec 3;9(12):e114212. doi: 10.1371/journal.pone.0114212. PMID: 25470778; PMCID: PMC4254940.
Groenen AG, Bazioti V, van Zeventer IA, Chen L, Groot HE, Balder JW, Zhernakova A, van der Harst P, Rimbert A, Kuivenhoven JA, Fu J, Westerterp M. Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity: A cross sectional study in the population-based LifeLines DEEP cohort. Atherosclerosis. 2022 Feb;343:20-27. doi: 10.1016/j.atherosclerosis.2022.01.008. Epub 2022 Jan 18. PMID: 35091264.
Singh K, Chandra A, Sperry T, Joshi PH, Khera A, Virani SS, Ballantyne CM, Otvos JD, Dullaart RPF, Gruppen EG, Connelly MA, Ayers CR, Rohatgi A. Associations Between High-Density Lipoprotein Particles and Ischemic Events by Vascular Domain, Sex, and Ethnicity: A Pooled Cohort Analysis. Circulation. 2020 Aug 18;142(7):657-669. doi: 10.1161/CIRCULATIONAHA.120.045713. Epub 2020 Jun 18. PMID: 32804568; PMCID: PMC7425196.
Duparc, T., Ruidavets, JB., Genoux, A. et al. Serum level of HDL particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study. Sci Rep 10, 8138 (2020). https://doi.org/10.1038/s41598-020-65100-2
Sokooti S, Flores-Guerrero JL, Kieneker LM, Heerspink HJL, Connelly MA, Bakker SJL, Dullaart RPF. HDL Particle Subspecies and Their Association With Incident Type 2 Diabetes: The PREVEND Study. J Clin Endocrinol Metab. 2021 May 13;106(6):1761-1772. doi: 10.1210/clinem/dgab075. PMID: 33567068; PMCID: PMC8118359.
Drew BG, Rye KA, Duffy SJ, Barter P, Kingwell BA. The emerging role of HDL in glucose metabolism. Nat Rev Endocrinol. 2012;8(4):237-245.
El Khoudary SR, Ceponiene I, Samargandy S, Stein JH, Li D, Tattersall MC, Budoff MJ. HDL (High-Density Lipoprotein) Metrics and Atherosclerotic Risk in Women. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2236-2244. doi: 10.1161/ATVBAHA.118.311017. PMID: 30026268; PMCID: PMC6202150.
Jin, Q., Lau, E.S.H., Luk, A.O. et al. High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank. Cardiovasc Diabetol 21, 293 (2022). https://doi.org/10.1186/s12933-022-01726-y
Arnold von Eckardstein, The encounter of elevated high-density lipoprotein cholesterol and high blood pressure lowers life expectancy, European Journal of Preventive Cardiology, 2023;, zwad108, https://doi.org/10.1093/eurjpc/zwad108
Tambalis K, Panagiotakos DB, Kavouras SA, Sidossis LS. Responses of blood lipids to aerobic, resistance, and combined aerobic with resistance exercise training: a systematic review of current evidence. Angiology. 2009 Oct-Nov;60(5):614-32. doi: 10.1177/0003319708324927. Epub 2008 Oct 30. PMID: 18974201.
Gao F, Ren Y-J, Shen X-Y, Bian Y-F, Xiao C-S, Li H. Correlation between the high density lipoprotein and its subtypes in coronary heart disease. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol. 2016;38(5):1906–14.
Li J-J, Zhang Y, Li S, Cui C-J, Zhu C-G, Guo Y-L, et al. Large HDL subfraction but not HDL-C is closely linked with risk factors, coronary severity and outcomes in a cohort of nontreated patients with stable coronary artery disease: a prospective observational study. Medicine (Baltimore). 2016;95(4):e2600.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
Save 10% off any plan with promo-code:
HEALTH10
Sign up
Sign up now and create your account. Use code HEALTH10 for a 10% discount on any plan. Don't miss out!
Organize
Bring all results from any laboratories to your account. You can enter your tests yourself, or we'll be happy to organize your files—whether in PDF, JPEG, CSV, or even screenshots.
Learn and improve
Once your information is stored in your account, dive into a wealth of insights about your results. If you have any more questions, we are here to answer them.
In the cardiovascular field, both HDL cholesterol (HDL-C) concentration and HDL particle size are independently associated with cardiovascular risk. In particular, large HDL particles appear to be protective in coronary artery disease. HDL particle (HDL-P) number has been proposed as improved inverse predictor of CVD compared to plasma HDL-C.
Here are five tips to increase large HDL particles:
Engage in aerobic exercise: Regular aerobic exercise, such as running or high-intensity workouts, has been associated with higher HDL levels. Aim for moderate to high-intensity exercises for at least 20 minutes per session. Increasing the duration of exercise has been shown to further boost HDL levels.
Replace unhealthy fats with healthy ones: Incorporate healthy fats into your diet while reducing unhealthy fats. Opt for sources like nuts, all-natural nut butters, seeds, avocado, and fatty fish such as salmon, trout, or sardines. Monounsaturated fats found in foods like avocados, nuts, and plant-based oils can specifically help increase HDL levels.
Quit smoking: Smoking negatively impacts HDL levels. Studies have shown that HDL levels significantly increase after smoking cessation. Seek support from organizations like Smokefree.gov, which provide resources and tips to help quit smoking.
Achieve and maintain a healthy weight: Losing excess weight can improve HDL levels. Start by tracking your food intake and maintaining a food journal. This simple practice can increase weight loss progress. Participants who kept a food journal as part of a nutrition intervention program lost more weight compared to those who didn't keep a record.
Reduce sugar intake and improve carbohydrate quality: High consumption of simple sugars and starches can lead to unfavorable lipid profiles, including low HDL levels. Opt for low-carbohydrate diets or focus on carbohydrate quality by choosing whole grains over refined grains. Limit sugar intake according to the American Heart Association guidelines: 6 teaspoons (or 24 grams) per day for women and less than 9 teaspoons (or 36 grams) per day for men.
Remember to consult with a healthcare professional or registered dietitian for personalized advice and guidance based on your specific health needs.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
for personal lab results
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
for personal lab results
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 per month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Unlocking the insights from your lab tests has never been this intuitive! We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into a treasure trove of testing data.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewGet a quick grasp of your test reports in minutes! Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Experience the power of clear, organized data visualization with Healthmatters.io — your key to understanding and taking charge of your health journey!
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional or business account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Apolipoprotein A-1, Apolipoprotein B, Apolipoprotein B/A1 Ratio, Apoprotein B100 (ApoB 100), HDL Large, HDL PARTICLE SUBFRACTIONS HDL, SMALL, HDL Size, HDL-2, HDL-3, HDL-P, IDL PARTICLE SUBFRACTIONS IDL, SMALL, IDL, LARGE, Large HDL-P, Large VLDL-P, LDL Medium, LDL Particle Number, LDL PARTICLE SUBFRACTIONS LDL, VERY SMALL-D, LDL Pattern, LDL Peak Size, LDL Size, LDL Small, LDL, LARGE-A, LDL, LARGE-B, LDL, VERY SMALL-A, LDL, VERY SMALL-B, LDL, VERY SMALL-C, LDL-P, LDL1 Pattern A, LDL2 Pattern A, LDL3 Pattern B, LDL4 Pattern B, Lipoprotein (a), LP PLA2 ACTIVITY, LP-IR Score, Small LDL-P, TOTAL PARTICLES TOTAL, HDL, TOTAL, NON-HDL, VLDL Cholesterol Cal, VLDL PARTICLE SUBFRACTION VLDL, SMALL, VLDL Size, VLDL, LARGE, VLDL, MEDIUM, VLDL-3
