Optimal Result: 102 - 200 mg/dL.

Apolipoprotein A1 (ApoA1) is the primary protein associated with high-density lipoprotein (HDL) particles, and plays a central role in reverse cholesterol transport.

HDL cholesterol (HDL-C) and ApoA1 concentrations are inversely related to the risk for coronary artery disease (CAD).

There are a variable number of ApoA1 proteins per HDL particle. Therefore, ApoA1 is not a 1:1 surrogate marker for HDL particles.

Similarly, the number of ApoA1 proteins and the amount of cholesterol contained in HDL particles is highly variable. This heterogeneity has led to unique clinical findings related to ApoA1 compared with HDL-C.

Reference ranges:

Males:

Age

Apolipoprotein A (mg/dL)

<24 months

Not established

2-17 years

Low: <115

Borderline low: 115-120

Acceptable: >120

>18 years

> or =120

Females:

Age

Apolipoprotein A (mg/dL)

<24 months

Not established

2-17 years

Low: <115

Borderline low: 115-120

Acceptable: >120

>18 years

> or =140

What does it mean if your Apolipoprotein A-1 result is too low?

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

Your apolipoprotein A levels may be low if you have:

- Low levels of apolipoprotein (familial hypoalphalipoproteinemia)

- Tangier disease, a rare inherited disorder that lowers the amount of HDL

- Hepatocellular disorders, which are certain types of liver problems

- Poorly controlled diabetes

- Nephritic syndrome, a group of kidney problems

- Chronic kidney (renal) failure

- Coronary artery disease. This means the arteries carrying blood to the heart become narrowed and hardened.

- Cholestasis, which means problems with the flow of bile from the liver

Smoking cigarettes, taking diuretics, or taking medicines that contain androgens can also cause lower levels of apolipoprotein A. 

------------------------------

- Low levels of apolipoprotein A1 (ApoA1) confer increased risk of atherosclerotic cardiovascular disease.

- ApoA1 below 25 mg/dL may aid in the detection of a genetic disorder such as Tangier disease.

- ApoA1 is often interpreted as a ratio with apolipoprotein B (ApoB).

- Low concentrations of ApoA1, but not HDL-C, are predictive of preclinical atherosclerosis as assed by computed tomography estimated coronary artery calcium (CAC) scoring.

What does it mean if your Apolipoprotein A-1 result is too high?

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

Your apolipoprotein A levels may be high if you:

- Have high levels of apolipoprotein (familial hyperalphalipoproteinemia)

- Have a genetic disorder called familial cholesteryl ester transfer protein deficiency, or CETP

- Take medicines containing extra estrogens

- Take niacin or statins, a type of cholesterol-lowering medicine

- Take statins

- Lose weight

------------------------------

- Increased ApoA1 concentrations are more strongly associated with a reduction in risk of a first myocardial infarction than HDL-C concentrations.

- Increased ApoA1, but not HDL-C concentrations, are associated with reduced cardiovascular events among statin-treated patients, even when LDL-C <50 mg/dL.

- In statin-treated patients, patients whose ApoA1 increased while on treatment were at lower risk than those whose ApoA1 did not increase.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals


  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;