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Research Vit B9 Folate
BiomeFx Microbiome Labs

Vit B9 Folate

Stool
Optimal Result: 0 - 10.795 Healthy Relative Abundance IQR (%).

Vitamin B9 (folate or tetrahydrafolate), is essential for healthy blood cells. Gut-derived folate is directly absorbed into the colon, contributing up to 37% of the daily recommended intake. If vitamin B9 producers are low, there could be low levels of this nutrient available to the body.

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A balanced and healthy gut microbiome is necessary for the proper digestion of food and the production of essential nutrients. Gut bacteria synthesize vitamin K2 and many of the B vitamins including biotin, cobalamin, folates, nicotinic acid, pantothenic acid, pyridoxine, riboflavin, and thiamine. Bacteroidetes synthesize the majority of B vitamins, however Fusobacteria, Proteobacteria, Firmicutes, and Actinobacteria are also capable of completing this task. Vitamin K2 is produced by many members of gut bacteria including Bacillus subtilis, E. coli, certain species of Lactobacillus, and others.

It appears that the most important factor in a well-rounded vitamin synthesis microbial network is the diversity of microbial species. For example, antibiotic usage is linked to poor vitamin K status, yet during periods of low vitamin K intake, a diverse and balanced gut microbiome can make up for dietary insufficiencies. In addition, vitamin synthesis requires a complex cross-feeding relationship among various bacterial species, underscoring the importance of diversity for vitamin production.

Generally speaking, Bacteroidetes produce the greatest number of B vitamins. Riboflavin and biotin are produced by nearly all members of Bacteroidetes, Fusobacteria, and Proteobacteria, while Firmicutes and Actinobacteria produce very little. Fusobacteria produces the greatest amount of vitamin B12. These biologically important bacteria can help you understand your unique vitamin needs based on the status of your gut microbiome.

What does it mean if your Vit B9 Folate result is too high?

Vitamin B9 (folate/tetrahydrofolate) is essential for healthy blood cells. It also promotes immune homeostasis and is a cofactor in several metabolic reactions, including DNA and amino acid synthesis. Vitamin B9 can be found in foods such as beef liver, green leafy vegetables, and asparagus. Vitamin B9 produced by intestinal bacteria is directly absorbed into the colon, contributing up to 37% of the daily recommended intake for B9. Vitamin B9 producers include Bacteroides fragilis, Prevotella copri, Clostridium difficile, Lactobacillus plantarum, L. reuteri, Streptococcus thermophilus, some species of Bifidobacterium spp, Fusobacteria, and Salmonella enterica.

Elevated levels of vitamin B9, or folate, in a gastrointestinal (GI) test can have several implications:

  1. Diet and Supplementation: High folate levels might indicate a diet rich in folic acid or the use of folate supplements. Since folate is a water-soluble vitamin, the body can excrete excess amounts through urine, so consuming more than needed typically does not cause problems.
  2. Vitamin B12 Deficiency: Elevated folate levels can sometimes suggest a vitamin B12 deficiency. This occurs because the body requires vitamin B12 to utilize folate effectively. Without sufficient vitamin B12, folate can accumulate in the blood. However, a folate test alone is not a reliable method for diagnosing vitamin B12 deficiency.
  3. Small Intestinal Bacterial Dysbiosis: Increased folate levels might also be associated with small intestinal bacterial dysbiosis. This condition can lead to an increased synthesis of folate by intestinal microbiota, resulting in elevated serum concentrations of the vitamin. Dysbiosis often occurs secondary to chronic enteropathy or other gastrointestinal disorders.

It is important to discuss elevated folate levels with a healthcare provider to determine the underlying cause and any necessary actions.

Frequently asked questions

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While we work with many popular labs, we welcome reports from lots of other places too.

It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.

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Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.

For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.

We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.

Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.

Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.

For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.

Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.

Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.

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Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.

You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.

Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.

Our goal has been to make your Healthmatters account as intuitive as possible.

We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.

1. Graph View:

Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.

2. All Tests View

Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.

3. Table View:

For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.

Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.

Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.

Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.

Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.

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