Histamine can be produced in the gut and travel to distant areas of the body, where it may induce unfavorable symptoms. Patients with an overabundance of histamine-producing bacteria should focus on strengthening intestinal barrier function, as a leaky gut can allow gut derived histamines to enter circulation and promote dietary intolerances or disruption in healthy allergic responses. High levels of gut derived histamine are associated with high abundance of Proteobacteria, Roseburia, Morganii morganii, and Klebsiella pneumoniae and decreased abundance of Bifidobacterium.
Histamine production
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