Hydrogen sulfide (H2S) is a byproduct of dietary sulfur and hydrogen gas. The bacteria that produce H2S are known as hydrogen sulfide producers or sulfate-reducing bacteria (SRB). H2S can be produced by numerous bacterial species of the Proteobacteria and Firmicutes phylum, including genera such as Clostridium, Escherichia, Salmonella, Klebsiella, Streptococcus, Desulfovibrio, and Enterobacter.
High-protein diets are believed to increase H2S by supplying the sulfide-rich amino acid, cysteine, which can be easily converted to H2S. Additionally, cruciferous vegetables (cabbage, cauliflower, kale, broccoli, etc) and durian fruit can directly release H2S during digestion.
At low concentrations, hydrogen sulfide is protective for the gut barrier. However, too much hydrogen sulfide leads to a disruption in ATP synthesis within mitochondria, which can destabilize the gut mucosal layer and promote inflammation.
Interestingly, sulfate reduction, acetogenesis, and methanogenesis compete for H2, which is produced by hydrogenotrophic microbes.
The end-product is dependent on substrate availability, hydrogenotrophic microbes. The end-product is dependent on substrate availability, thermodynamics, and pH. The human gut environment favors methanogenesis, due to the neutral pH of stool and low sulfate levels in diet.88 However, if consuming high amounts of dietary sulfate (i.e. bread, beer, wine) with low stomach acid, sulfate reduction may overtake methanogenesis.88 As with many things in the human body, balance is key.
Overproduction of hydrogen sulfide is detrimental to intestinal health. Reducing H2S production can be accomplished by limiting cysteine and homocysteine in diet, which are sulfur containing amino acids. Increasing H2S production can be accomplished through amino acid supplementation and cruciferous vegetable intake.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
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Causes of High H2S Levels
→ High-protein diets, especially those rich in the sulfur-containing amino acid cysteine, can increase H2S production by gut bacteria.
→ Consumption of cruciferous vegetables (e.g., cabbage, cauliflower, kale, broccoli) and durian fruit can directly release H2S during digestion.
Effects of Excessive H2S
→ At low concentrations, H2S is protective for the gut barrier.
→ However, excessive H2S can disrupt ATP synthesis within mitochondria, leading to destabilization of the gut mucosal layer and promoting inflammation.
Factors Influencing H2S Production
→ Sulfate reduction, acetogenesis, and methanogenesis compete for hydrogen gas (H2) produced by hydrogenotrophic microbes.
→ The end-product depends on substrate availability, thermodynamics, and pH.
→ The neutral pH of stool and low dietary sulfate levels in the human gut favor methanogenesis over sulfate reduction.
→ Consuming high amounts of dietary sulfate (e.g., from bread, beer, wine) with low stomach acid can shift the balance towards sulfate reduction.
Strategies to Reduce H2S Production
→ Limiting cysteine and homocysteine intake, which are sulfur-containing amino acids, can help reduce H2S production.
In summary, elevated H2S levels in the gut, often due to high-protein diets or certain food sources, can disrupt the gut mucosal layer and promote inflammation. Maintaining a balance between H2S production and other competing metabolic processes is crucial for intestinal health.
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Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
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1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
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Acetate production, Akkermansia muciniphila, Alpha Diversity, Ammonia production, Beta Diversity, Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bilophila wadsworthia, Butyrate production, Clostridium scindens, Escherichia coli, Estrogen recycling (Estrobolome), Eubacterium rectale, Faecalibacterium prausnitzii, Firmicutes:Bacteroidetes Ratio, GABA production, Glutathione production, Gut Microbiome Index (GMI), Histamine production, Hydrogen Sulfide (H2S) production, Indole production, Lactate production, Limosilactobacillus reuteri, Methane Production, Oxalobacter formigenes, P-Cresol (Phenol), Parabacteroides goldsteinii, Parabacteroides merdae, Pathogen Control Index, Phocaeicola vulgatus, Polyamine production, Prevotella:Bacteroides Ratio, Propionate production, Proteobacteria:Actinobacteria Ratio, Resistome Occurrence Index, Roseburia intestinalis, Ruminococcus bromii, Sutterella wadsworthensis, Vit B1 Thiamin, Vit B12 Cobalamin, Vit B2 Riboflavin, Vit B5 Pantothenic acid, Vit B6 Pyridoxine, Vit B7 Biotin, Vit B9 Folate, Vit K2 Menaquinone
