Optimal Result: 0 - 2.9 mcg/g creat.

Heptacarboxyporphyrin is a Porphyrin.

Porphyrins are precursors of heme and usually only occur in urine in negligible amounts.

However, disorders in heme biosynthesis lead to the syndrome of porphyria with increased formation and excretion of porphyrins. Porphyrias can be hereditary-related or acquired through exogenous influences such as alcohol consumption or lead poisoning. Different enzymes of the heme biosynthesis can be deficient, thus, several different porphyrias can be distinguished. Since these share some common symptoms, chromatographic measurement of the porphyrins is the only way to enable an exact diagnosis.

Porphyrias, which can be inherited or acquired, are often diagnosed with the aid of information regarding the distribution profile of individual porphyrin intermediates in urine. The term “porphyria” is derived from the Greek word porphyria, meaning “purple pigment”.

Porphyrins are particularly well suited as biomarkers for two reasons. First, the pathway is highly active, so any disturbance tends to cause rapid and relatively large accumulations of intermediates. Second, the enzymes of the porphyrin-producing pathway are widely distributed in human tissues and some of them are highly sensitive to the presence of various toxins.

Alterations of porphyrin synthesis that are not due to hereditary or toxic disturbances of porphyrin metabolism are adaptive responses. Such responses caused by alcohol or other drugs may not lead to clinical consequences. However, these disturbances often initiate biochemical and clinical manifestation of genetic porphyrias that previously may have been latent. Once initiated, the symptoms may be long-lasting, especially if the offending toxicant is not identified and removed or avoided. Numerous toxic porphyrias are precipitated by environmental mediators.

Multiple environmental and nutritional factors can cause additive effects. For example, hexachlorobenzene-induced porphyria is accentuated by estrogens and attenuated by vitamin C. The estrogen effect increases the susceptibility of women to porphyrias. Aluminum inhibits some heme synthetic enzymes and has been implicated in causing porphyria in chronic hemodialysis patients, whom are often aluminum overloaded.

Lead intoxication causes signs and symptoms similar to acute intermittent porphyria including abdominal pain, constipation and vomiting. However, anemia which is often found with lead intoxication may be absent in lower lead exposures that generate porphyria, indicating that the overall flux through the porphyrin pathway is not strongly reduced even though significant amounts of intermediates are spilled, due to the toxicant effect.


– https://www.ncbi.nlm.nih.gov/pubmed/10830610

– https://www.ncbi.nlm.nih.gov/pubmed/15967199

– https://www.ncbi.nlm.nih.gov/pubmed/10787385

– https://pdfs.semanticscholar.org/285c/c5c73b7ce1b39abb1917168934ece917a434.pdf

– https://www.ncbi.nlm.nih.gov/pubmed/9114276

– https://www.ncbi.nlm.nih.gov/pubmed/16782144

– https://www.ncbi.nlm.nih.gov/pubmed/11353126

– https://www.tandfonline.com/doi/abs/10.1080/00039899909602482

– https://www.ncbi.nlm.nih.gov/pubmed/3615245

What does it mean if your Heptacarboxyporphyrin result is too high?

Possible reasons for elevated Heptacarboxyporphyrin levels:

– Environmental Toxin-induced Porphyrinurias (Arsenic, Hexachlorobenzene, Dioxin, Polybrominated biphenyl

– Alcohol (chronic hepatic porphyria – late)

– Inherited factors: Porphyria cutanea tardia (PCT) and hepatoerythropoietic porphyria (HEP)

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan

  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan

  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals

  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: