Coproporphyrin III is a porphyrin derivative.
Small amounts of porphyrins (coproporphyrin) are excreted in normal human urine. Coproporphyrin also is present in bile and feces.
By convention, the term porphyria is used to define those disease states that have a hereditary basis and increased urinary or fecal excretion of uroporphyrins and coproporphyrins.
Porphyria can affect the nervous system or skin. Sometimes both are affected. The condition may or may not cause symptoms. Symptoms may develop over hours or days and last for days or weeks. Symptoms may be brought on by various medicines, smoking, drinking alcohol, weight loss, pregnancy, infections, or major surgery.
– Skin problems after sun exposure
– Pain, especially belly pain
– Numbness and tingling
– Digestive upset
– Personality changes
– Mental disorders
– Rapid heart rate and high blood pressure
– Painful urination
Increased levels of coproporphyrins could be a sign of porphyria (ex. “Variegate porphyria”)
Mild elevations of urine coproporphyrins (eg, as high as two times the reference range) are common and nonspecific. Fasting, subtle liver disease, or normal variations are the most common causes of elevated urine coproporphyrins. In such cases, patients may be incorrectly labeled as having porphyria.
Excess coproporphyrin excretion is also observed in a wide variety of conditions including:
– Hemolytic anemias
– Liver disease
– Lead poisoning
– Arsenic poisoning
– Hepatitis C
– Hodgkin’s disease
The screening test for coproporphyrinuria has been especially useful for detecting exposure to lead.
In Rotor syndrome, total urinary coproporphyrin is increased two- to fivefold over normal.
A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease.
If acute porphyria, which is often misdiagnosed, is suspected, please discuss further steps with your healthcare professional.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month