Chloride, Urine

Optimal Result: 110 - 250 mmol/24 hr.

Chloride is the most abundant ion outside of cells. It is important for maintaining osmotic pressure, nerve cell function, and fluid balance. The urine chloride test is used primarily in cases of suspected metabolic alkalosis. Under normal circumstances, sodium and urine are excreted into the urine at a steady, equal rate. Plasma levels of chloride tend to mirror those of sodium (i.e., as sodium levels increase in plasma, chloride levels increase). Nevertheless, urine chloride levels can be used to investigate certain diseases and disorders, though urine chloride levels are rarely measured alone. Most often, they are measured in conjunction with urine pH, sodium, and potassium levels. A urine chloride test may also be ordered along with other labs needed to diagnose metabolic alkalosis and other acid-base disturbances, such as arterial blood gases. Acetazolamide, corticosteroids, NSAIDs, and diuretics can interfere with the test.

Normal Ranges for Urine Chloride:

40-224 mmol/24 hours







What does it mean if your Chloride, Urine result is too low?

In metabolic alkalosis were blood volume is decreased, urine sodium levels may be high while urine chloride levels may be low. Very low levels of urine chloride (less than 10 to 20 mEq/L) generally occur after excessive vomiting or nasogastric suction, diuretic induced alkalosis, and certain other forms of metabolic alkalosis. On the other hand, primary hyperaldosteronism, licorice ingestion, and mineralocorticoid excess syndrome cause low urine chloride levels but generally above 25 mEq/L.

Some specific causes of low urine chloride levels are:

- Metabolic alkalosis

- Sodium retention

- Cushing syndrome

- Decreased salt intake

- Diuretics (thiazide and loop diuretics)

- Excess licorice ingestion (glycyrrhizic acid)

- Primary hyperaldosteronism

- Mineralocorticoid excess syndrome

What does it mean if your Chloride, Urine result is too high?

In metabolic acidosis, the excretion of sodium and potassium in the urine goes down while urine chloride excretion stays the same or increases. Conditions that cause excess sodium excretion in the kidney also cause increased urine chloride, since chloride follows sodium in sodium-chloride co-transporters. Increased sodium chloride intake can also lead to high urine chloride levels as can any situation in which calcium resorption by the kidney is impaired.

Some specific causes of high urine chloride levels are:

- Adrenal insufficiency

- Salt-losing nephropathy

- Polyuria (increased urination)

- Excessive salt intake

- Metabolic acidosis

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan

  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan

  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals

  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: