Urinalysis

Coproporphyrin I

A healthy result should fall into the range 5.6 - 28.6 mcg/g creat.

Coproporphyrin I is a porphyrin metabolite arising from heme synthesis.

Porphyrins are natural chemicals in the body that help form many important substances in the body. One of these is hemoglobin, the protein in red blood cells that carries oxygen in the blood.

Porphyrins build up among patients with hereditary enzyme disorders known as porphyrias. Porphyrias affect the heme biosynthetic pathway and cause increased urine excretion of porphyrinogens, by-products known as porphyrins and porphyrinogen precursors-including delta aminolevulinic acid (ALA) and porphobilinogen (PBG).

Porphyrins can be measured in the urine or blood.

References:

https://porphyriafoundation.org/patients/about-porphyria/testing-porphyria/tests-porphyria-diagnosis

https://r.details.loinc.org/LOINC/13960-0.html?sections=Comprehensive

https://www.gdx.net/core/interpretive-guides/Porphyrins-IG.pdf

http://www.hmdb.ca/metabolites/HMDB0000643

https://jamanetwork.com/journals/jama/article-abstract/298948

http://www.clinsci.org/content/65/5/527

https://www.ncbi.nlm.nih.gov/pubmed/12699241

Coproporphyrin I result calculator

insert the value from you Coproporphyrin I test result.

What does it mean if your Coproporphyrin I result is too high?

Porphyrins appear elevated in urine when the cellular pathway for heme synthesis is blocked by natural or man-made toxicants or when genetic disorders that affect the enzymes of the porphyrin pathway are present.

Coproporphyrin and uroporphyrin excretion in urine is markedly increased during a cute attacks of hereditary coproporphyria. Increased uroporphyrinogen, uroporphyrin, and coproporphyrin excretion occurs in porphyria cutanea tarda.

Increased levels of coproporphyrins may be a sign of:

- Congenital erythropoietic porphyria

- Hepatic coproporphyria

- Sideroblastic anemia

- Variegate porphyria

- Hereditary coproporphyria

- Liver disease

- Bone marrow disorders

- Lead poisoning

- Arsenic poisoning

Increases in urine coproporphyrin are sometimes not due to Porphyria. When total urine porphyrins are increased due to Porphyria Cutanea Tarda (PCT) or Hepatoerythropoietic Porphyria (HEP), the increase is predominantly accounted for by uroporphyrin and heptacarboxyl porphyrin.

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted.

WE SUPPORT 1000+ BIOMARKERS INCLUDING BIOMARKERS FROM YOUR FAVOURITE LABS

Healthmatters.io customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."

Healthmatters.io thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."

Healthmatters.io thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."



Pricing
Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.