AA/EPA

Optimal result: 12 – 125 Ratio

The higher the AA/EPA ratio, the higher are the levels of cellular inflammation.

An AA/EPA ratio of 1.5 is considered to be ideal, since this is the ratio found in the Japanese population having the greatest longevity and the lowest incidence of cardiovascular disease.

A lower AA/EPA ratio indicates a better balance of “good” and “bad” eicosanoids in your body. The average AA/EPA of Americans is approximately 11, and for patients with inflammatory conditions and neurological disorders, the AA/EPA ratio will be in excess of 20.

How to reduce and improve the AA/EPA ratio through dietary methods:
The fastest way to reduce the AA/EPA ratio is to increase the intake of high-purity omega-3 fatty acid concentrates and to reduce the consumption of arachidonic acid (AA) and omega-6 fatty acids (LA).

Increase omega-3 rich food sources:
– Seaweed, nori, spirulina, and chlorella
– Chia seeds
– Hemp seeds
– Flax seeds
– Walnuts
– Edamame
– Kidney beans

EPA is anti-inflammatory and should balance the levels of pro-inflammatory arachidonic acid. Although EPA can be produced from the essential fatty acid, ALA, dietary intakes of this fatty acid are generally poor. The conversion also requires the action of the delta-6 desaturase enzyme that may be low due to inadequate Zn, Mg, or vitamins B3, B6, and C. Such an enzyme impairment would be indicated if EPA is low and ALA is normal or high.

High levels of saturated, monounsaturated, trans fatty acids, and cholesterol also slow the conversion of ALA to EPA.

Decrease AA omega-6 rich food sources:

– Chicken
– Eggs
– Beef
– Sausage, franks, bacon, and ribs
– Fish
– Burgers
– Cold cuts
– Pork

This test measures the ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in plasma. This ratio of the principle omega-3 and omega-6 fatty acids is a measure of the body’s eicosanoid balance. Balancing these eicosanoids in the body is an excellent way
for managing heart disease and other chronic and inflammatory processes.

An AA/EPA ratio of 1.5 is considered to be ideal, since this is the ratio found in the Japanese population having the greatest longevity and the lowest incidence of cardiovascular disease.

A lower AA/EPA ratio indicates a better balance of “good” and “bad” eicosanoids in your body. The average AA/EPA of Americans is approximately 11, and for patients with inflammatory conditions and neurological disorders, the AA/EPA ratio will be in excess of 20.

This test measures the ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in plasma. This ratio of the principle omega-3 and omega-6 fatty acids is a measure of the body’s eicosanoid balance. Balancing these eicosanoids in the body is an excellent way
for managing heart disease and other chronic and inflammatory processes.

This test measures the ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in plasma. This ratio of the principle omega-3 and omega-6 fatty acids is a measure of the body’s eicosanoid balance. Balancing these eicosanoids in the body is an excellent way
for managing heart disease and other chronic and inflammatory processes.

AA/EPA RANGES CELLULAR INFLAMMATION FUTURE STATE OF WELLNESS
1.5 to 3 Low Excellent
3 to 6 Moderate Good
7 to 15 Elevated Moderate
> than 15 High Poor

Even though cellular or chronic inflammation is silent (absent of pain signals), it can be measured with a number of medical tests.

The AA/EPA Ratio is one of the most common tests for cellular inflammation.

The two other common tests are:

  • hs-C-reactive protein (hs-CRP)
  • Nuclear factor kappa-B (NF-kB)

References:

– https://www.ncbi.nlm.nih.gov/pubmed/17398308

– http://www.clevelandheartlab.com/providers/the-science/

– http://www.clevelandheartlab.com/wp-content/uploads/2018/11/CHL-D003-JUL2018-Artery-Wall-OnePager.pdf

– https://www.medicalnewstoday.com/articles/323144.php

– https://www.nutraingredients-usa.com/Article/2010/11/08/Omega-3-ALA-intakes-enough-for-EPA-DPA-levels-for-non-fish-eaters

– https://epi.grants.cancer.gov/diet/foodsources/fatty_acids/table4.html

AA/EPA
Healthmatters dashboard showing biomarker trend graph

Every lab result you’ve ever had, charted and explained.

Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.

Start with my report →
Beyond AA/EPA — 10,000+ markers explained
One AA/EPA result tells you where you are. Your history tells you where you’re heading. Upload your past lab reports and see this marker — and every marker on them —every marker charted against your own lab’s ranges.
Start with this report →
Healthmatters timeline preview showing biomarker trends over time
Clinical Sources & References

All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.

Article Review Log
Written by Healthmatters Editorial Team
Healthmatters Lifetime Plan

Pay $250. Track your health forever

One payment. No renewals. Yours for life.

10,000+ biomarkers explained · trends over time

See other plans →
Secure checkout via Stripe · GDPR & HIPAA
We accept results from any lab
LabCorp Quest Diagnostics Genova Diagnostics DUTCH Test Doctor's Data Vibrant America ZRT Laboratory Cyrex Labs + any other lab

What members are saying

★★★★★ 10,000+ happy members
★★★★★

"Watching my numbers move over the years — instead of forgetting last time's results — completely changed how I manage my health."

Daniel
Member since 2022
★★★★★

"Living across several countries made keeping my lab results organized a real challenge. Healthmatters brought my results from the USA, Spain, and Germany together — 20 years of history, with long-term trends instead of scattered reports."

Ben
Member since 2021 · tracks across countries
★★★★★

"Standard lab ranges are too wide for how I practice — 'normal' isn't optimal. I set my own bands, so a client sees yellow before a marker goes officially out of range. That's the conversation I want to be having."

Dr. Alexandra
Functional medicine · 6 yrs on Pro