Essential and Metabolic Fatty Acids Markers (RBCs)

Pentadecanoic

Optimal result: 0.07 – 0.15 wt %

By Healthmatters Editorial Team

Peer-reviewed sources

– When measuring fatty acids in whole plasma (not erythrocytes), increased levels of pentadecanoic acid correlate to a more than twofold higher risk of coronary heart disease.

– Pentadecanoic acid is positively correlated with total dairy intake.

– As a possible way to lower penntadecanoic acid level one can reduce overall dairy intake as part of a healthy diet that is rich in fruits, vegetables, and whole grains, but low in sodium, red meats, dairy, sugar sweetened beverages and trans fats.

– Pentadecanoic acid can accumulate in a vitamin B12 deficiency.

Decreased dietary intake of dairy products and fiber may contribute to low levels. Literature is evolving as to their health benefits, and lower levels have been associated with risk for cardiometabolic diseases, inflammation, Alzheimer’s disease, multiple sclerosis, and nonalcoholic steatohepatitis.

Pentadecanoic acid is an odd numbered fatty acid with a 15-carbon backbone (15:0) and widely considered as one biomarker to assess dairy consumption/intake. It is not normally synthesized by humans, but is found in trace amounts in dairy products (milk fat) and ruminant meat fat.

References:

– https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C68413

– https://www.ncbi.nlm.nih.gov/pubmed/25647578

– https://www.ahajournals.org/doi/10.1161/JAHA.113.000393

– https://www.ncbi.nlm.nih.gov/pubmed/14518600?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/7644455?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/17921367?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/22585901?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/20089734?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/21068345?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/21660519?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/9925119?dopt=Abstract

– https://www.ncbi.nlm.nih.gov/pubmed/23466047?dopt=Abstract

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Clinical Sources & References

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