8-hydroxy- 2’-deoxyguanosine (8-OHdG) is a byproduct of oxidative damage to guanine bases in DNA.
It is used as a biomarker for oxidative stress and carcinogenesis. It has been studied to estimate DNA damage after exposure to carcinogens including tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.
8-OHdG levels are positively associated with markers of inflammation and evening cortisol, indicating that increased physiological or psychosocial stress is associated with increased oxidative damage.
References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313038/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865279/
https://pubmed.ncbi.nlm.nih.gov/28319849/
https://pubmed.ncbi.nlm.nih.gov/16128745/
https://pubmed.ncbi.nlm.nih.gov/14687888/
https://pubmed.ncbi.nlm.nih.gov/28065503/
https://www.nature.com/articles/srep32581
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6189-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982778/
https://pubmed.ncbi.nlm.nih.gov/22576471/
https://pubmed.ncbi.nlm.nih.gov/23788962/
https://pubmed.ncbi.nlm.nih.gov/33005115/
https://pubmed.ncbi.nlm.nih.gov/32944094/
https://pubmed.ncbi.nlm.nih.gov/27575995/
https://pubmed.ncbi.nlm.nih.gov/27757204/
Elevated 8-OHdG indicates oxidative damage to DNA. Diseases including cardiovascular disease, Chronic obstructive pulmonary disease (COPD), cancer, thyroid disease, and diabetes have been associated with excessive concentrations of 8-OHdG.
Minimizing exposure to xenobiotics and cigarette smoke, stress management, and increasing antioxidant intake may prevent further oxidative damage.
Increased physical activity is associated with a reduction in urinary 8-OHdG levels.
Green tea catechins decreased 8-OHdG concentrations in patients with Alzheimer’s disease.
$79 per year
$6.60 per month billed annually
Use promocode
$15 per month
$79 per year
$250 single payment
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn More
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
% Omega 3s, % Omega 6s, % Omega 9s, % Saturated Fats, 8-OHdG (urine), a-Linolenic, AA / EPA, Arachidic, Arachidonic, Arsenic (whole blood), Behenic, Cadmium (whole blood), Coenzyme Q10, Ubiquinone (serum), Copper (plasma), Dihomo-g-linolenic, Docosahexaenoic, Docosapentaenoic, Docosatetraenoic, Eicosadienoic, Eicosapentaenoic, Elaidic, g-Linolenic, Glutathione (whole blood), Lead (whole blood), Lignoceric, Linoleic, Linoleic / DGLA, Lipid Peroxides (urine), Magnesium (RBC), Manganese (whole blood), Margaric, Mercury (whole blood), Nervonic, Oleic, Omega 3 Index, Omega 6s / Omega 3s, Palmitic, Palmitoleic, Pentadecanoic, Potassium (RBC), Selenium (whole blood), Stearic, Tin (whole blood), Tricosanoic, Vaccenic, Zinc (plasma)
