4 hydroxy estrone (4-OH-E1) and estradiol (4-OH-E2) are metabolites of estrone and estradiol and are very reactive estrogens. They are highly prone to the formation of catechol estrogen-derived 3,4 semi-quinones, which are potent, electrophilic, free radical-generating molecules that have been shown to lead to DNA mutagenesis. Indeed, 4 hydroxy E1 and E2 are the most potent and potentially carcinogenic estrogens.
References:
- http://www.ncbi.nlm.nih.gov/pubmed/16411670
- http://www.pnas.org/content/94/20/10937.long
- http://www.ncbi.nlm.nih.gov/pubmed/14749240
- https://www.ncbi.nlm.nih.gov/pubmed/25048790
- http://www.cqzb.cn/references.htm
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632771/
- https://www.sciencedirect.com/science/article/pii/S1658077X16300960
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
Save 10% off any plan with promo-code:
HEALTH10
The bad news may be that you are making too much of the 4-hydroxyestrogens and not methylating them well. The good news is that you know this is happening and can do things to change how your body metabolizes estrogens, and in doing so decrease your breast cancer risk. Nutritional intervention (e.g., foods rich in DIM or indole-3-carbinol) can be used to shift estrogens in the direction of 2-hydroxylation, which is safer. Additionally, methylation of estrogen metabolites can be supported nutritionally (e.g., methyl donors such as vitamin B12, folic acid, SAM-e, and foods such as onions, garlic and beets). And the effectiveness of this intervention can be evaluated by measuring the ratio of 2- and 4-methoxyestrone to 2- and 4-hydroxyestrone.
- Improve methylation by adding cofactors (B12, folate) or methyl donors (betaine, dimethyl glycine)
- Consider genetic testing for COMT and CYP1B1 activity, particularly if positive family history
- Reduce stress: COMT is involved in the metabolism of epinephrine, reducing availability for estrogen metabolism
- Increase inhibitors of CYP1B1 (Grapefruit, Ginseng)
- Avoidance of CYP1B1 inducers (Polycyclic aromatic hydrocarbons)
Evaluate methylation activity:
- Serum Homocysteine
- Serum B12 or methylation
- Urinary FIGLU
- Urinary xanthurenate
Other potential protective factors:
- Glutathione (reduction of estrogen quinones)
- Resveratrol (prevents estrogen quinone formation)
- Selenium, zinc, magnesium
High levels of 4-hydroxylated estrogens (4-OH-E2 and 4-OH-E1) and/or low levels of their methylated forms are associated with increased breast cancer risk.
Lifestyle modifications help reduce excessive levels of the parent estrogens (estradiol, estrone) and their down-stream hydroxylated metabolites.
Some of these lifestyle modifications include:
- maintaining a healthy weight,
- exercising,
- eating green leafy vegetables
- avoiding excess red meat,
-assuring that iodine and selenium are within healthy ranges that protect the breast epithelium, using bioidentical hormones (particularly natural progesterone),
- avoiding toxic foods and chemicals as much as possible.
EAT FIBER:
Try to consume 40 to 60 grams of fiber every day. Fiber helps to bind excessive hormones and metabolites that are excreted in your stool. The addition of fiber will also help to bind and excrete excessive fats.
EAT FLAX SEEDS:
Flax seeds – Flax seeds are a promoter of CYP1A1 and an inhibitor of CYP1B1. Thus, flax seeds are promoters of 2 hydroxylation (neutral estrogen), and inhibitors of 4 hydroxylation (potentially undesirable). Flax also has shown to inhibit CYP3a4 and reduce the excretion of 16OHE1, another potentially problematic estrogen.
EAT GREEN VEGGIES:
Eat raw organic broccoli, Brussels sprouts, kale, or cauliflower three times per week. A recent clinical trial found that these vegetables produce the substances indole – 3 – carbinol (I3C) and diindolymethane (DIM). They help to stimulate or make more CYP1A1, which is responsible for making more 2-OHE1. Increased ratios of 2-OHE1 to 16a-OHE1 are thought to be protective against breast cancer formation.
EAT BERRIES:
Numerous types of berries (blackberries, raspberries, grapes, blueberries) are a rich source of polyphenolic compounds, including ellagic acid. Ellagic acid is a promoter of glutathione transferase (GSTM) as well as NQO1 (quinone reductase). These 2 enzymes are important in the detoxification of 3,4 semi-quinones. Additionally, ellagic acid has been shown to increase DNA repair genes, as well as reduce DNA adducts that have been formed by carcinogens.
GRAPEFRUIT AND CITRUS PEEL:
Grapefruit & Citrus peel are sources of hesperidin. Hesperidin at high doses inhibits CYP1B1 and also CYP3a4. Grapefruit is notorious for inhibiting CYP3a4. Citrus peel contains a considerable amount of hesperidin, that is especially true of dried tangerine peel. An assortment of studies done on hesperidin have found an overall increase in blood flow and circulation, reduction in blood pressure, and reduction in symptoms of cell adhesion factors, which may disrupt cancer activities.
DHA:
Take 600 – 800 mg of DHA omega 3 fatty acids per day. The easiest way to do this is through supplementation. This helps to prevent overall inflammation in the body.
MULTIVITAMIN:
Take a good multivitamin in order to ingest adequate amounts of nutrients necessary to convert estrogen metabolites to the protective methyl forms such as 2-MeOHE1. Specifically you want adequate amounts of methyl folic acid, methyl cobalamin, and vitamin B6. (Consult your health care practitioner prior to taking a multivitamin).
AVOID PROCESSED SUGARS:
Avoid processed sugars or excessive amounts of natural sugars. Excess sugar is stored as fat in humans. Estrogen loves to store itself in fat cells. These stored estrogens can be released or converted, causing more effects of estrogen dominance. This can increase a person’s risk of estrogen-induced cancers.
EXERCISE:
Exercise 5 times per week for 30 minutes each time, including 3 days of resistance training. This helps to control excessive body weight and increases natural regulation of sex hormones.
AVOID CHEMICALS:
Avoid contact or ingestion of pesticides and/or chemical irritants. Many common chemical products cause DNA damage in cells, making them more susceptible to developing cancers.
AVOID GENETICALLY MODIFIED FOODS:
Avoid genetically modified foods or foods with chemical preservatives. Many of these types of foods have been shown to cause cellular damage.
AVOID EXCESS CONSUMPTION OF SOY PRODUCTS:
Avoid excess consumption of processed soy products as they may increase your risk of estrogen metabolite production.
LOWER STRESS LEVELS:
Keep your stress levels as low as possible.
Sign up
Sign up now and create your account. Use code HEALTH10 for a 10% discount on any plan. Don't miss out!
Organize
Bring all results from any laboratories to your account. You can enter your tests yourself, or we'll be happy to organize your files—whether in PDF, JPEG, CSV, or even screenshots.
Learn and improve
Once your information is stored in your account, dive into a wealth of insights about your results. If you have any more questions, we are here to answer them.
Generally no treatment recommended
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
for personal lab results
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
for personal lab results
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 per month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Unlocking the insights from your lab tests has never been this intuitive! We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into a treasure trove of testing data.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewGet a quick grasp of your test reports in minutes! Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Experience the power of clear, organized data visualization with Healthmatters.io — your key to understanding and taking charge of your health journey!
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional or business account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
16-OH-E1, 16-OH-E1 Postmenopausal, 2-Methoxy-E1, 2-Methoxy-E1 Postmenopausal, 2-Methoxy-E2, 2-Methoxy-E2 Postmenopausal, 2-OH-E1, 2-OH-E1 Postmenopausal, 2-OH-E2, 2-OH-E2 Postmenopausal, 4-OH-E1, 4-OH-E1 Postmenopausal, 4-OH-E2, 4-OH-E2 Postmenopausal, Estradiol (E2), Estradiol (E2) Postmenopausal, Estriol (E3), Estriol (E3) Postmenopausal, Estrone (E1), Estrone (E1) Postmenopausal, Total Estrogen, Total Estrogen Postmenopausal
