A healthy result should fall into the range 0.2 - 0.7 ng/mg.
Estradiol (E2) is the major estrogen and is recognised for producing the majority of the functions of estrogen in the body. It is critical for the development of female reproductive organs, for producing female secondary sexual characteristics and during the menstrual cycle and, with progesterone, prepares the endometrium for implantation. It helps vaginal lubrication, reduces urinary tract infections and increases sexual desire. It is also important for brain, enhancing memory and mood. Estradiol (E2) is about 10 times as potent as E1 and about 80 times as potent as E3 in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of E1 during the reproductive years of females. Thus it is the predominant estrogen during reproductive years both in terms of serum levels and estrogenic activity. E2 to E1 conversion is generally favoured and the metabolites in the Dutch test tell you whether this occurring correctly. Incorrect conversion greatly increases the risk factors for certain reproductive cancers.
After menopause, estrogen levels drop dramatically, as there are few follicles in your ovaries. Additionally, these follicles are no longer growing and producing the estradiol spikes that occur during the menstrual cycle.
During perimenopause, people may notice that their body changes in response to these lower levels of estrogen.
Symptoms of low estrogen during perimenopause and menopause
- Vaginal dryness (known as atrophic vaginitis or vulvovaginal atrophy) is common. Without enough estrogen, the walls of the vagina are not able to maintain their thickness and are no longer as moist.
- Hot flashes are associated with decreasing levels of estrogen, and can be treated using estrogen therapy. Phytoestrogens, or estrogens from food, may be moderately beneficial, but more research is needed.
- Osteoporosis is a risk for post-menopausal people as estrogen levels decrease.
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