A healthy result should fall into the range 0 - 1.2 ng/mg.

Research and clinical studies show that the 2-hydroxylated estrogens (2-OH E2 and 2-OH E1) are a safer pathway of hydroxylation than the 4-hydroxyestrogens (4-OH E2 and 4-OH E1), which bind to and damage DNA, leading to mutations that are associated with increased breast cancer risk. If either 4-OH-E2 or 4-OH-E1 are higher than reference range, and not well methylated, this may indicate higher risk for DNA damage, mutations, and risk for developing breast cancer.

Hydroxylation of estrogens in the 2-position of estradiol (2-OH-E2) and estrone (2-OH-E1) is considered a safer pathway for metabolism than the 4-position hydroxylations of these estrogens. The 2-position hydroxylations (considered safer) are increased with cruciferous vegetables (and extracts of them) as well as iodine. The most commonly used are indole-3-carbinol (I3C) and its metabolite diindolylmethane (DIM). Iodine also increases the 2-hydroxylation of estrogens, with a slight increase in 4-hydroxylation. The more dangerous 4-hydroxylated estrogen metabolism is enhanced by exposure to environmental toxins, mostly petrochemical-based products but also heavy metals, that induce 4-hydroxylation pathway enzymes, and cause formation of Reactive Oxygen Species (ROS) that co-oxidize the catechol estrogens to more dangerous estrogen quinones.

2-OH-E2 result calculator

insert the value from you 2-OH-E2 test result.

Is your 2-OH-E2 too high or too low?
Upload your lab report and instantly interpret your result.

DIY Health One

One Lab Report Interpretation

  • One lab report interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Pay per additional interpretations
  • Report uploading support*

15 $

Analyze and Interprete Now

*Additional costs may apply

DIY Health Track

Unlimited Lab Report Interpretations

  • Unlimited lab report interpretations
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Online support
  • We do the uploading for you*

59 $/year

Analyze and Interprete Now

*4 report uploads by our team are included per year

Sign Up, Upload Tests, Get Insights and Improve with HealthMatters.io.

Sign up now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.