16-OH-E1

DUTCH

A healthy result should fall into the range 0.7 - 2.6 ng/mg.

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. It is a potent estrogen similarly to estrone, and it has been suggested that the ratio of 16α-hydroxyestrone to 2-OH-E1, the latter being much less estrogenic in comparison and even antiestrogenic in the presence of more potent estrogens like estradiol, may be involved in the pathophysiology of breast cancer. Conversely, 16α-hydroxyestrone may help to protect against osteoporosis.

Synthetic and Natural Estrogens:

Estrone (E1), estradiol (E2) and estriol (E3) are the three estrogens. Synthetic estrogen (premarin) is made up of E1 and E2 estrogen. E1 is the main estrogen that the body makes post menopausally, and most researchers believe that high E1 levels increase the risk of breast cancer. 

Estrogen Metabolism:

The metabolism of estrogen in women changes after menopause. The body metabolizes estrogen into two major pathways and one minor. The two major are 2 and 16-hydroxyeone (2-OH and 16 OH, respectively). The minor pathway is 4-hydroxyestrone (4-OH). 2-OH is the good metabolite. 2-OH does not stimulate cell growth and it blocks the action of stronger estrogens that may be carcinogenic. 

16-OH has a significantly stronger estrogenic activity, and studies show that it may increase the risk of breast cancer. 

4-OH is also not desirable as it may directly damage DNA and cause mutations, thus it is thought to promote cancer development. Premarin breaks down exclusively into 4-hydroxyestrogen.

 

16-OH-E1 result calculator

insert the value from you 16-OH-E1 test result.

Is your 16-OH-E1 too high or too low?
Upload your lab report and instantly interpret your result.

DIY Health One

One Lab Report Interpretation

  • One lab report interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Pay per additional interpretations
  • Report uploading support*

15 $

Analyze and Interprete Now

*Additional costs may apply

DIY Health Track

Unlimited Lab Report Interpretations

  • Unlimited lab report interpretations
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Online support
  • We do the uploading for you*

59 $/year

Analyze and Interprete Now

*4 report uploads by our team are included per year

Sign Up, Upload Tests, Get Insights and Improve with HealthMatters.io.

Sign up now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.