Succinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.

Succinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.

Succinyl CoA becomes succinic acid using succinyl CoA synthetase. This reaction produces NADH which directly provides electrons for the electron transport chain or respiratory chain. Succinic acid requires the enzyme succinate dehydrogenase to become fumarate. This enzyme is ironbased and requires vitamin B2 to support flavin adenine dinucleotide (FAD) as a redox coenzyme. Succinate dehydrogenase plays a critical role in mitochondrial metabolism. Impairment of this enzyme’s activity has been linked to a variety of diseases such as cancer and neurodegenerative diseases.

Succinyl CoA becomes succinic acid using succinyl CoA synthetase. This reaction produces NADH which directly provides electrons for the electron transport chain or respiratory chain. Succinic acid requires the enzyme succinate dehydrogenase to become fumarate. This enzyme is ironbased and requires vitamin B2 to support flavin adenine dinucleotide (FAD) as a redox coenzyme. Succinate dehydrogenase plays a critical role in mitochondrial metabolism. Impairment of this enzyme’s activity has been linked to a variety of diseases such as cancer and neurodegenerative diseases.

Succinylacetone (SA) is used for the diagnosis and monitoring of patients with tyrosinemia type I (Tyr I). Succinylacetone is exclusively elevated in blood and urine of patients with tyrosinemia type I . As urinary Succinylacetone concentration is much higher than blood, Succinylacetone is usually tested in urine samples.

Sulfate is associated with your body’s use of glutathione, an amino acid critical for removing toxins that is also a powerful antioxidant.

Sulfocysteine is the product of sulfite-dependent cleavage of cystine. In the pathway, cysteine becomes sulfite, which converts to sulfate via sulfite oxidase + Mo. If the pathway is blocked, sulfocysteine builds up.

Sulfocysteine is the product of sulfite-dependent cleavage of cystine. In the pathway, cysteine becomes sulfite, which converts to sulfate via sulfite oxidase + Mo. If the pathway is blocked, sulfocysteine builds up.

Sulfur, an essential mineral, plays a pivotal role in various metabolic processes, including the synthesis of amino acids like methionine and cysteine, and in the production of glutathione, a critical antioxidant that protects cells from damage caused by free radicals and heavy metals. Elevated levels of sulfur in urine can indicate a high intake of sulfur-rich foods, such as cruciferous vegetables, garlic, and onions, or supplements containing sulfur amino acids. Conversely, low sulfur levels may suggest dietary deficiencies or impaired sulfur metabolism, potentially linked to conditions like reduced glutathione synthesis, impaired detoxification pathways, and metabolic dysregulation. Additionally, sulfur is involved in the methylation process, a critical biochemical pathway essential for DNA synthesis and repair, neurotransmitter production, and the regulation of gene expression. 

Normal CSF is crystal clear. However, as few as 200 white blood cells (WBCs) per mm3 or 400 red blood cells (RBCs) per mm3 will cause CSF to appear turbid (=cloudy).

Xanthochromia is a yellow, orange, or pink discoloration of the CSF, most often caused by the lysis of RBCs resulting in hemoglobin breakdown to oxyhemoglobin, methemoglobin, and bilirubin.

Sutterella wadsworthensis is a fascinating microbe that's part of the normal gut flora in many people. This gram-negative, non-spore-forming bacterium is known for its ability to thrive in bile-rich environments, which explains its presence in the intestines and bile ducts. While S. wadsworthensis is found in about 50-60% of healthy individuals, its role in gut health is still being explored. On a BiomeFX report, elevated levels of S. wadsworthensis might catch your attention. This could indicate potential changes in your gut microbiome balance, possibly linked to dietary factors like high consumption of saturated fats or taurine-rich foods. Some studies have associated higher levels of S. wadsworthensis with conditions like inflammatory bowel disease and autism spectrum disorders, though the exact relationship is still under investigation. It's important to note that while its presence isn't inherently harmful, an overgrowth might be worth discussing with your healthcare provider, especially if you're experiencing any digestive issues or have concerns about your metabolic health.

Function:

Synapsin I, also known as phosphosynaspin I, is a major immunoreactive protein found in most neurons of the central and peripheral nervous systems. It is a member of a group of neuronal phosphoproteins involved in the regulation of neurotransmitter release. Synapsin I is present in the nerve terminal of axons, specifically in the membranes of synaptic vesicles.

Antibodies Appear:

- Demyelinating Diseases

- Inhibited Neurotransmitter Release

- Lupus

- Multiple Sclerosis

Known Cross-Reactions:

Gliadin (a protein of wheat)

Function:

Synapsin I, also known as phosphosynaspin I, is a major immunoreactive protein found in most neurons of the central and peripheral nervous systems. It is a member of a group of neuronal phosphoproteins involved in the regulation of neurotransmitter release. Synapsin I is present in the nerve terminal of axons, specifically in the membranes of synaptic vesicles.

Antibodies Appear:

- Demyelinating Diseases

- Inhibited Neurotransmitter Release

- Lupus

- Multiple Sclerosis

Known Cross-Reactions:

Gliadin (a protein of wheat)

Synoviocytes are essential for joint health and the production of synovial fluid, but their percentage is not a standard component of synovial fluid analysis. Instead, the focus of this analysis is on the presence and percentages of white blood cells to diagnose joint-related conditions.