Explore our database of over 10000 laboratory markers.
Search and Understand 10000 Biomarkers
Optimal range: 1.03 - 1.2 Ratio
Compares 8 different biomarkers
– 4 biomarkers with a methyl group to give
– 4 biomarkers that have had a methyl group removed
The clinical utility of the Methylation Balance Ratio is that it represents a potential way to detect subtle methylation imbalance prior to alterations in the SAM/SAH ratio.
Methylated Metabolites are:
- SAM
- Methionine
- Betaine
- Serine
Un-Methylated Metabolites are:
- SAH
- Homocysteine
- DMG
- Sarcosine
Optimal range: 2.2 - 6.4 micromol/L
The SAM/SAH ratio is commonly referred to as the “Methylation Index” in the literature and has well- documented clinical associations.
Global methylation is dependent on two key factors: adequate SAM supply and SAH removal.
The SAM/SAH ratio has been proposed to indicate the likelihood of hyper- or hypo-methylation.
Overall, the SAM/SAH ratio is under tight homeostatic control. SAM levels remain fairly stable due to denovo synthesis and feedback mechanisms. Given this, alterations in the methylation index are more likely a result of SAH fluctuations.
Optimal range: 0.2 - 0.65 Ratio
A comparison of 2-Methoxyestrone with 2OHE1 allows insight into methylation pathways. If the methylation ratio is on the low end of the reference range, consider adding supplements to improve methylation. If needed, consider further testing for methylation defects.
Optimal range: 0 - 14 mmol/mol creatinine
Methylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Optimal range: 0.19 - 2.7 mmol/mol creatinine
Methylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Optimal range: 0.15 - 1.7 mmol/mol creatinine
Methylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Optimal range: 0 - 5.7 mmol/mol creatinine
LEARN MOREOptimal range: 0.15 - 2.96 mmol/mol
Methylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Reference range: Negative, Positive
Reduced methylenetetrahydrofolate reductase (MTHFR) enzyme activity is a genetic risk factor for hyperhomocysteinemia, especially when present with low serum folate levels. Two common variants in the MTHFR gene result in reduced enzyme activity. The "thermolabile" variant C677T [NM 005957.3: c.665C>T (p.A222V)] and A1298C [c. 1286A>C (p.E429A)] occur frequently in the general population.
Optimal range: 0 - 1.64 ug/mg creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. In one step of metabolism, vitamin B12 promotes the conversion of methylmalonyl CoA (a form of MMA) to succinyl Coenzyme A. If there is not enough B12 available, then the MMA concentration begins to rise, resulting in an increase of MMA in the blood and urine. The measurement of elevated amounts of methylmalonic acid in the blood or urine serves as a sensitive and early indicator of vitamin B12 deficiency.
Optimal range: 0 - 1.9 mmol/mol creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Optimal range: 0 - 2.3 mcg/mg creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Optimal range: 0 - 2.5 ug/mg
The measurement of elevated amounts of methylmalonic acid in the blood or urine serves as a sensitive and early indicator of vitamin B12 deficiency.
Optimal range: 0 - 3.5 ug/mg
The measurement of elevated amounts of methylmalonic acid in the blood or urine serves as a sensitive and early indicator of vitamin B12 deficiency.
Optimal range: 0 - 2.3 mmol/mol creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Optimal range: 0 - 2 mmol/mol creatinine
Other names: Methylmalonic Acid or MMA
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. In one step of metabolism, vitamin B12 promotes the conversion of methylmalonyl CoA (a form of MMA) to succinyl Coenzyme A. If there is not enough B12 available, then the MMA concentration begins to rise, resulting in an increase of MMA in the blood and urine. The measurement of elevated amounts of methylmalonic acid in the blood or urine serves as a sensitive and early indicator of vitamin B12 deficiency.
Optimal range: 0 - 2.3 mmol/mol creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Optimal range: 0 - 5.2 mmol/mol creatinine
LEARN MOREOptimal range: 0 - 1.9 mmol/mol creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Optimal range: 0 - 1.9 mmol/mol creatinine
Methylmalonic Acid (MMA) is formed from propionylCoA via methylmalonyl-CoA. Major dietary sources of propionyl-CoA include valine, isoleucine, methionine, threonine, and odd chain fatty acids. MethylmalonylCoA is converted to succinyl-CoA to feed the Citric Acid Cycle via the enzyme methylmalonyl-CoA mutase. This enzyme is very vitamin B2 dependent. In B12 deficiency, methylmalonyl-CoA is hydrolyzed to methylmalonic acid.
