NAPR is a metabolite of 1-bromopropane (nPB), which is used as a liquid or gaseous solvent with a characteristic hydrocarbon odor. It is widely used for metal cleaning, foam gluing, and dry cleaning. nPB has been classified as a human carcinogen. Occupation exposure to nPB in higher concentrations has resulted significant injuries. Reported symptoms of overexposure affect the nervous system and include confusion, slurred speech, dizziness, paresthesias, difficulty walking, unusual fatigue and headaches, development of arthralgias, visual disturbances (difficulty focusing), and muscle twitching. Symptoms may persist over one year.
- Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system.
- Acute exposure can lead to headaches.
- Individuals who have high levels of 1-bromopropane should examine their environment to determine their exposure route.
- 1-bromopropane elimination can be accelerated by the supplementation of glutathione (reduced) either oral, intravenous, transdermal, or its precursor N-acetyl cysteine(NAC).
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