The Bone Fraction on Labcorp's Alkaline Phosphatase (ALP) Isoenzyme Panel represents the portion of alkaline phosphatase originating from bone tissue. Elevated levels of the bone fraction may indicate conditions such as Paget's disease, osteomalacia, or bone metastases, which involve increased bone turnover. This isoenzyme is specifically measured to differentiate the source of elevated ALP levels, allowing healthcare providers to pinpoint bone-related disorders. The ALP isoenzyme panel utilizes electrophoresis or other advanced techniques to separate and identify different ALP isoenzymes, providing valuable insights into bone health. By evaluating the bone fraction, clinicians can accurately diagnose bone diseases and guide appropriate treatment.

Bone isoenzymes, specifically bone-specific alkaline phosphatase (BSAP), are important biomarkers used to assess bone metabolism and turnover. These enzymes play a crucial role in bone formation and mineralization processes.

Bone isoenzymes are a subset of alkaline phosphatases (ALP), which are hydrolytic enzymes that function in an alkaline environment. They are primarily produced by osteoblasts, the cells responsible for bone formation, and are present in the plasma membrane of these cells. The main function of bone isoenzymes is to hydrolyze phosphates, which are then used in the formation of proteins, nucleotides, and the mineralization of bone.

Bordetella pertussis causes whooping cough, a worldwide infectious disease that is transmitted from person to person by droplet infection. Especially children at the age of 0-4 years are affected, and the mortality of infected infants is high.

Bordetella pertussis is the bacterium responsible for causing whooping cough, a highly contagious respiratory illness. The Bordetella pertussis toxin (PT) IgG antibody test is an immunoassay (IA) designed to detect the presence of IgG antibodies against the pertussis toxin. These antibodies are produced by the immune system in response to an infection with Bordetella pertussis or, in some cases, following vaccination.

The presence of IgG antibodies to the pertussis toxin can indicate either a past infection with Bordetella pertussis or a response to a recent vaccination, as the pertussis vaccine (DTP or DTaP) contains inactivated components of the toxin. This marker is particularly useful for diagnosing recent or past infections, as well as for assessing immunity in individuals who may have been vaccinated or exposed to the bacteria.

Boron is normally found in hair but the correlations among Boron absorption, and tissue and hair levels of Boron have yet to be determined. Boron has a low order of toxicity, but excessive intake induces riboflavinuria. Boron is frequently high in hair in association with high levels of potentially toxic elements (i.e. lead, mercury, and cadmium) and exposure to toxic chemicals. Exogenous contamination of hair with B is possible since B is present in some soap. Boron is also present in some cleaners, cements, ceramics and glass.

Borrelia afzelii is a species of Borrelia, a bacterium that can infect various species of vertebrates and invertebrates.

B. afzelii and B. garinii are the primary causes of Lyme disease in Europe and Asia. Coinfection by this Borrelia species with one or more pathogens can occur, carried by the vector, which appears to be in most cases the tick.

Borrelia afzelii is a species of Borrelia, a bacterium that can infect various species of vertebrates and invertebrates. B. afzelii and B. garinii are the primary causes of Lyme disease in Europe and Asia.

Coinfection by this Borrelia species with one or more pathogens can occur, carried by the vector, which appears to be in most cases the tick. In Europe the related genospecies Borrelia afzelii is associated with both EM and acrodermatitis chronica atrophicans (ACA), and several European studies have found compelling evidence for B. afzelii infection in patients with morphea.

Borrelia afzelii is a species of Borrelia, a bacterium that can infect various species of vertebrates and invertebrates. B. afzelii and B. garinii are the primary causes of Lyme disease in Europe and Asia. Coinfection by this Borrelia species with one or more pathogens can occur, carried by the vector, which appears to be in most cases the tick. In Europe the related genospecies Borrelia afzelii is associated with both EM and acrodermatitis chronica atrophicans (ACA), and several European studies have found compelling evidence for B. afzelii infection in patients with morphea.

What is Borrelia andersonii – IgG?

Borrelia andersonii is a species of Borrelia, a genus of spiral-shaped bacteria that includes several species known to cause tickborne illnesses such as Lyme disease and relapsing fever. While Borrelia andersonii has not been definitively linked to human disease, it has been isolated from Ixodes ticks (the same ticks that transmit Lyme disease) and from wild animals in parts of North America, suggesting it may play a role in the broader ecology of tickborne infections.

The IgG antibody test for Borrelia andersonii measures the body’s long-term immune response to this bacterium. IgG antibodies typically appear weeks after exposure and can remain in the bloodstream for months or even years, indicating past exposure or infection.

What Does a Medium Result Mean?

A medium IgG result indicates a moderate level of antibodies, which may reflect:

• A recent or past exposure to Borrelia andersonii

• A low-level or cross-reactive immune response, possibly due to exposure to a related Borrelia species

• A borderline finding, which may or may not be clinically significant

Follow-up testing and clinical evaluation can help determine whether additional investigation or treatment is necessary.

What is Borrelia andersonii – IgM?

Borrelia andersonii is a species within the Borrelia genus, a group of spiral-shaped bacteria that includes known causes of Lyme disease and relapsing fever. Borrelia andersonii has been found in Ixodes ticks and certain wild animals in North America, but it is not currently recognized as a confirmed human pathogen. However, its presence on testing panels may indicate exposure to Borrelia bacteria or potential cross-reactivity with related species.

The IgM antibody test for Borrelia andersonii detects early immune response—specifically IgM antibodies, which typically appear within 1–2 weeks of infection or exposure. This makes IgM testing useful for identifying recent or possible current exposure to Borrelia species.

What Does a Medium Result Mean?

A medium IgM result indicates a moderate level of early antibodies, which could reflect:

• An early or low-level immune response to a Borrelia species

• A resolving immune reaction, if exposure occurred recently

• A borderline or nonspecific result, which should be interpreted with caution

In the absence of symptoms or supporting test results, a medium IgM result is typically not diagnostic and may not require treatment.

Borrelia burgdorferi is spirochete class bacterium. B. burgdorferi sensu stricto, B. burgdorferi sensu lato, B. burgdorferi afzelii and B. burgdorferi garinii spirochetes enter the human body through tick bites.

Mixed with tick saliva, Borrelia travels through the circulation and enters different tissues. In some untreated cases, symptoms of pathogenic invasion have involved neurologic, cardiac, or joint disorders. Borrelia pathogenesis can break the blood-brain barrier, which allows invasion of the central nervous system, resulting in neuroborreliosis.

Borrelia burgdorferi sensu lato (B.b.s.l.) with the following subspecies:

- USA: Borrelia burgdorferi sensu stricto (B.b.s.s.), Borrelia andersonii, Borrelia americanum, B. carolinensis, B. bissettii, B. myamotoi

- Europe: Borrelia afzelii, Borrelia garinii, B. spielmanii, B. valaisiana, B. lusitaniae, B. bavariensis

- Asia: Borrelia japonica, B. rutdi, B. tanukii, B. sinica, B. yangtze

Borrelia burgdorferi is spirochete class bacterium. B. burgdorferi sensu stricto, B. burgdorferi sensu lato, B. burgdorferi afzelii and B. burgdorferi garinii spirochetes enter the human body through tick bites.

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.