Hydroxyproline is a collagen related amino acid. Hydroxyproline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver. Hydroxyproline is necessary for the construction of the body’s major structural protein, collagen. Hydroxyproline is present in essentially all tissues and all genetic types of collagen.

- Hydroxyproline is the key factor in stabilizing collagens.

- Hydroxyproline is abundant in meat and low in plant-based foods. Meat intake increases levels of proline and hydroxyproline.

- Increased hydroxyproline has been found in collagen catabolism (bone resorption, increased reactive oxygen species [ROS]), tissue degradation, muscle damage, or other conditions such as Paget's disease or Alzheimer's disease.

- Proline and hydroxyproline both negatively correlated with a higher likelihood of anxiety, depression, and psychoses.

Hydroxyproline is a collagen related amino acid. Hydroxyproline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver. Hydroxyproline is necessary for the construction of the body’s major structural protein, collagen. Hydroxyproline is present in essentially all tissues and all genetic types of collagen.

Hydroxyproline is the key factor in stabilizing collagens.

- Hydroxyproline is abundant in meat and low in plant-based foods. Meat intake increases levels of proline and hydroxyproline.

- Increased hydroxyproline has been found in collagen catabolism (bone resorption, increased reactive oxygen species [ROS]), tissue degradation, muscle damage, or other conditions such as Paget’s disease or Alzheimer’s disease.

- Proline and hydroxyproline both negatively correlated with a higher likelihood of anxiety, depression, and psychoses.

- Plasma hydroxylproline may be reduced with fatigue (caused by deprivation of rest and sleep; a physical stress condition) or oxidative stress.

Hydroxyproline is a collagen related amino acid. Hydroxyproline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver. Hydroxyproline is necessary for the construction of the body’s major structural protein, collagen. Hydroxyproline is present in essentially all tissues and all genetic types of collagen.

The Hydroxyproline to Proline Ratio describes the relationship between Proline and Hydroxyproline and can be looked at in relation to your collagen metabolism.

The Hydroxyproline to Proline Ratio describes the relationship between Proline and Hydroxyproline and can be looked at in relation to your collagen metabolism.

Type 1 diabetes, commonly referred to as insulin-dependent diabetes (IDDM), is caused by pancreatic beta-cell destruction that leads to an absolute insulin deficiency. The clinical onset of diabetes does not occur until 80% to 90% of these cells have been destroyed. Prior to clinical onset, type 1 diabetes is often characterized by circulating autoantibodies against a variety of islet cell antigens, including glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA2), and insulin. The autoimmune destruction of the insulin-producing pancreatic beta cells is thought to be the primary cause of type 1 diabetes. The presence of these autoantibodies provides early evidence of autoimmune disease activity, and their measurement can be useful in assisting the physician with the prediction, diagnosis, and management of patients with diabetes.

Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes).

IDL Cholesterol is a plasma lipoprotein. Cholesterol and triglycerides are insoluble in water and therefore these lipids must be transported in association with proteins. Lipoproteins are complex particles with a central core containing cholesterol esters and triglycerides surrounded by free cholesterol, phospholipids, and apolipoproteins, which facilitate lipoprotein formation and function.

IFN gamma refers to Interferon-gamma. Interferon-gamma is one of the cytokines assessed in the CytoDx Cytokine Response Profile offered by Diagnostic Solutions Laboratory. Cytokines are important mediators of immune responses, and their imbalances have been linked to chronic inflammation and autoimmune diseases. 

IFN gamma is categorized as a pro-inflammatory cytokine and is associated with Th1 cell responses. Th1 cells are involved in cellular immunity and play a critical role in defense against intracellular pathogens, such as viruses and certain bacteria. Interferon-gamma is a key cytokine produced by Th1 cells and is essential for activating immune responses against these intracellular pathogens.

Testing for IgE antibodies is essential in diagnosing and managing allergic diseases. IgE is linked to allergic reactions, and its level can indicate the severity of symptoms and the risk of severe reactions like anaphylaxis. Testing helps identify specific allergens, crucial for effective allergy management. It also monitors the effectiveness of treatments such as immunotherapy, where decreasing IgE levels signify positive responses. In chronic allergic conditions like asthma and eczema, IgE testing confirms diagnoses and guides treatment. Elevated IgE levels can even predict the development of allergies, especially in children, allowing for early intervention. Understanding IgE's role has also led to targeted therapies like anti-IgE monoclonal antibodies, effective in treating severe allergic asthma. Overall, IgE antibody testing is a key component in personalized allergy care.