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Vitamins & Minerals

Nicotinamide

Optimal Result: 5.2 - 72.1 ng/mL.

What is Niacin/Vitamin B3?

Niacin (nicotinic acid) is a water-soluble vitamin that is also referred to as vitamin B3.

Nicotinamide (nicotinic acid amide) is the derivative of niacin that is incorporated into the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Both nicotinic acid and nicotinamide are absorbed from the normal diet. Nicotinamide is the form of vitamin B3 that is commonly found in nutritional supplements and used to fortify foods. Nicotinic acid is available both over the counter and with a prescription as a cholesterol-lowering agent. 

The nicotinamide moiety of NAD and NADP serves as an electron acceptor or donor in biological oxidation-reduction (redox) reactions catalyzed by several hundred different enzymes. NAD serves as the cofactor for enzymes that break down (catabolize) carbohydrates, fats, proteins, and alcohol while NADP supports biosynthetic (anabolic) reactions, including the synthesis of all macromolecules, such as fatty acids and cholesterol.

Nicotinamide has also been shown to serve as a cofactor in adenosine diphosphate (ADP)-ribose transfer reactions that play an integral part in deoxyribonucleic acid (DNA) repair calcium mobilization.

Studies of cultured cells and animal models suggest that ADP-ribose polymer-mediated DNA repair and cyclic ADP-ribose-mediated cell-signaling pathway may play a role in cancer prevention.

The amino acid tryptophan can be metabolically converted into niacin. Vitamin B3, also called niacin and nicotinic acid, is a water soluble B vitamin. It plays a role in releasing energy from carbohydrates and fats, metabolizes proteins, and assists in the production of some hormones and in the formation of red blood cells. Niacin is also thought to prevent and treat diabetes, improve circulation (as inositol hexaniacinate); and relieve arthritis.

The beneficial use of niacin (nicotinic acid, but not niacinamide) to prevent or treat elevated blood lipids and reduce cardiovascular disease risk is documented. 

What does it mean if your Nicotinamide result is too high?

Large amounts of niacin may result in "niacin intolerance" in 15-40% of people who try it and the unpleasant side effect of "skin-flushing" (similar to hot flashes). The RDA for niacin is only 13-18 mg. Vitamin B3 has been used orally and intravenously in connection with various health conditions including; high triglycerides, dysmenorrhea, hypothyroidism, and multiple sclerosis.

What does it mean if your Nicotinamide result is too low?

Niacin deficiency can result from inadequate dietary intake of niacin and/or the amino acid tryptophan. Tryptophan, obtained from the breakdown of dietary protein, can be converted to nicotinamide by liver enzymes that require vitamin B6, riboflavin, and iron. Deficiencies of these constituents can contribute to the development of niacin deficiency.

- Hartnup's disease, a hereditary disorder that reduces tryptophan absorption, can lead to niacin deficiency. 

- Carcinoid syndrome diverts tryptophan to the increased production of serotonin and can reduce the production of nicotinamide.

- Prolonged treatment with isoniazid has also been associated with niacin deficiency.

- Niacin deficiency can affect the skin, digestive system, and the nervous system. 

Severe niacin deficiency, referred to as pellagra, has been associated with the "four Ds": 
- dermatitis, 
- diarrhea, 
- dementia, 
and ultimately death.

Pellagra dermatitis is characterized by a thick, scaly, darkly pigmented rash that develops symmetrically in areas exposed to sunlight. 

Digestive system symptoms include: 
- vomiting, 
- constipation or diarrhea, 
- and a bright red tongue.

Pellagra can also cause neurologic symptoms, including: 
- apathy, 
- fatigue, 
- depression, 
- headache, 
- disorientation, 
- and memory loss.

Frequently asked questions

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It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.

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For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.

We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.

Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.

Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.

For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.

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Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.

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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.

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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.

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Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.

2. All Tests View

Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.

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For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.

Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.

Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.

Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.

Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.

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Yes, you can! Simply go to the "Invite Doctor" section, enter your doctor’s email address, and send the invitation. Your doctor will receive an email with secure access to view your results. You can revoke this access at any time. All shared information is securely encrypted and protected for your privacy.
Yes, you can! Go to the Graph view or Spreadsheet view. In the top-right corner, click "Export to Excel," and the file will be downloaded to your device.

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