Methylmalonic Acid, Serum

Vitamins & Minerals

A healthy result should fall into the range 0 - 378 nmol/L.

What is Methylmalonic acid?

Methylmalonic acid is a compound that reacts with vitamin B-12 to produce coenzyme A (CoA).

What is Coenzyme A?

Coenzyme A is essential to normal cellular function. Coenzyme A is involved in hundreds of reactions and is required for the metabolism of fatty acids, carbohydrates, amino acids and ketone bodies. 

Why perform the methylmalonic acid test?

When vitamin B-12 deficiencies occur, methylmalonic acid levels increase. Measurement of methylmalonic acid through the methylmalonic acid test can provide your doctor with information about an existing vitamin deficiency, especially if the B-12 deficiency is mild or just beginning.

The methylmalonic acid test is more sensitive than the vitamin B-12 test. As a result, it’s better able to identify vitamin B-12 deficiencies at the lower end of the normal range. The methylmalonic acid test is often used along with the vitamin B-12 test or to clarify ambiguous vitamin B-12 test results.

The methylmalonic acid test may also be ordered if the results of other blood tests are abnormal. For instance, abnormal results from a homocysteine test may prompt your doctor to order the methylmalonic acid test.

What are Symptoms of B-12 deficiency:

  • cognitive impairment
  • gait or walking abnormalities
  • irritability
  • jaundice
  • peripheral neuropathy

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