HMW (high molecular weight) glutenin is a protein component found in wheat gluten. Gluten is a mixture of proteins found in wheat, barley, and rye that provides the elasticity and texture in dough and other baked goods.
The gluten proteins can be divided into two main groups: the gliadins and the glutenins. The glutenins can be further divided into the low molecular weight (LMW) glutenins and the high molecular weight (HMW) glutenins.
The HMW glutenins are larger and more complex proteins than the LMW glutenins, and they play an important role in determining the quality and elasticity of wheat dough. The HMW glutenins are involved in the formation of strong and stable gluten networks, which are essential for producing high-quality bread and other baked goods.
Scientists have found that the genetic makeup of the HMW glutenin proteins can affect the baking quality and nutritional properties of wheat. This has led to efforts to develop wheat varieties with specific HMW glutenin genes that produce better-quality bread or have improved nutritional properties.
In individuals with celiac disease or gluten sensitivity, the immune system reacts to certain gluten proteins, including HMW glutenin, leading to inflammation and damage to the small intestine. This can cause a range of symptoms and long-term health problems.
The presence of antibodies to HMW glutenin in the blood can be used as a diagnostic tool for celiac disease, along with other markers such as antibodies to gliadin and tissue transglutaminase. Testing for these antibodies can help healthcare professionals confirm a diagnosis of celiac disease or gluten sensitivity and guide appropriate treatment and management.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Antibodies to HMW (high molecular weight) glutenin are immunoglobulins produced by the immune system in response to the presence of HMW glutenin proteins in the body. These antibodies are part of the immune system's defense mechanism against foreign substances, including harmful pathogens and substances that the body recognizes as allergens or antigens.
In the context of celiac disease and non-celiac gluten sensitivity, individuals with these conditions produce antibodies to certain gluten proteins, including HMW glutenin. These antibodies recognize and bind to the HMW glutenin proteins, triggering an immune response that can cause inflammation and damage to the lining of the small intestine.
It is important to note that the production of antibodies to HMW glutenin alone is not sufficient to diagnose celiac disease or gluten sensitivity. Additional testing, such as a small intestinal biopsy, may be necessary to confirm the diagnosis.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedMonthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
AA/EPA, Akkermansia muciniphila, Alloprevotella, Alpha Gliadin IgG, Alpha-Beta Gliadin IgG, Amylase/Protease Inhibitors IgG, Anti-Actin IgG, Anti-LPS (IgG + IgM), Anti-LPS IgA, Anti-Zonulin IgG, Arachidonic acid (AA), Bacillus coagulans, Bacteroides, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium lactis, Clostridium, Clotridiales Incertae Sedis IV, Copper to Zinc Ratio, Eggerthella lenta, Escherichia coli Nissle, Faecalibacterium, Farinins IgG, Gamma Gliadin IgG, Globulins IgG, Gluteomorphin IgG, HMW Glutenin IgG, Lactobacillus animalis, Lactobacillus paracasei, Linoleic acid (LA), LMW Glutenin IgG, Omega Gliadin IgG, Oscillospira, Porphyromonas gingivalis, Prodynorphin IgG, Pseudobutyrivibrio, Purinin IgG, Serpin IgG, Streptococcus, Total Omega-6, Tyzzerella