Actin is responsible for regulating paracellular flow across the intestinal epithelium. However, increased levels of actin suggest epithelial cell damage leading to increased intestinal permeability and decreased barrier function.
Intestinal Permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin. Gliadin (a glycoprotein present in wheat) activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules. The cytoskeleton is also made up of proteins, which comprise a network of thin, overlapping fibers known as the actin-myosin network. This partnership between the actin-myosin network proteins controls the permeability of the tight junctions, and thus the intestinal barrier.
Antibodies to actin suggest leaky gut diagnosis.
Consider subsequent testing of your gut bacteria profile to identify an optimum dosage of the right probiotic necessary to help fix your leaky gut. A combination therapy may be recommended using probiotics, L-glutamine, L-arginine and Omega3 supplementation.
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month