Zonulin acts as the gate-keeper between the cells of the intestinal lining in order for nutrients and other essential molecules to be transported in and out of the intestine. However, when leaky gut is present, the intestinal lining is compromised allowing larger protein molecules to get into the bloodstream thereby causing an immune response.
Intestinal Permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin. Gliadin (a glycoprotein present in wheat) activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules. The cytoskeleton is also made up of proteins, which comprise a network of thin, overlapping fibers known as the actin-myosin network. This partnership between the actin-myosin network proteins controls the permeability of the tight junctions, and thus the intestinal barrier.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Increased levels of zonulin/anti-zonulin antibodies indicate leaky gut condition.
Consider subsequent testing of your gut bacteria profile to identify an optimum dosage of the right probiotic necessary to help fix your leaky gut. A combination therapy may be recommended using probiotics, L-glutamine, L-arginine and Omega3 supplementation.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.Get Started
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month
AA/EPA, Akkermansia muciniphila, Alloprevotella, Alpha Gliadin IgG, Alpha-Beta Gliadin IgG, Amylase/Protease Inhibitors IgG, Anti-Actin IgG, Anti-LPS (IgG + IgM), Anti-LPS IgA, Anti-Zonulin IgG, Arachidonic acid (AA), Bacillus coagulans, Bacteroides, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium lactis, Clostridium, Clotridiales Incertae Sedis IV, Copper to Zinc Ratio, Eggerthella lenta, Escherichia coli Nissle, Faecalibacterium, Farinins IgG, Gamma Gliadin IgG, Globulins IgG, Gluteomorphin IgG, HMW Glutenin IgG, Lactobacillus animalis, Lactobacillus paracasei, Linoleic acid (LA), LMW Glutenin IgG, Omega Gliadin IgG, Oscillospira, Porphyromonas gingivalis, Prodynorphin IgG, Pseudobutyrivibrio, Purinin IgG, Serpin IgG, Streptococcus, Total Omega-6, Tyzzerella