High levels of lipopolysaccharides (LPS) antibodies are indicative of penetration of LPS into the bloodstream. LPS binds to cells lining the gut and increases synthesis of pro-inflammatory substances.
Intestinal Permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin. Gliadin (a glycoprotein present in wheat) activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules. The cytoskeleton is also made up of proteins, which comprise a network of thin, overlapping fibers known as the actin-myosin network. This partnership between the actin-myosin network proteins controls the permeability of the tight junctions, and thus the intestinal barrier.
Increased levels of lipopolysaccharides antibodies indicate leaky gut condition.
Consider subsequent testing of your gut bacteria profile to identify an optimum dosage of the right probiotic necessary to help fix your leaky gut. A combination therapy may be recommended using probiotics, L-glutamine, L-arginine and Omega3 supplementation.
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