Epstein-Barr virus (EBV), or herpes type IV, is a DNA virus composed of linear double stranded DNA genome enclosed by a capsid and membrane derived envelope made from a variety of glycoproteins. EBV is ubiquitous. Infection often occurs during childhood and infects about 95% of the population. In adolescence, infectious mononucleosis, the “kissing disease,” can occur, during which up to 20% of B-cells become infected with the virus. Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Citrullination of EBV occurs when citrullin, an amino acid that is created by post translational modification of arginine residues in proteins, is catalyzed by an enzyme called peptidyl arginine deiminase (PAD). Citrullinated EBV could act as a target for anti-citrullinated protein antibodies (ACPAs), autoantibodies that are directed against peptides and proteins that are citrullinated, and this characteristic may account for the link between EBV infection and the onset or progression of ACPAs production. Citrullination of a variety of proteins is emerging as an essential component of inflammation in a variety of autoimmune diseases including neuroautoimmunity.
Increased risk of multiple autoimmunities including joint, lupus, neurological, thyroid, and liver, and type 1 diabetes and multiple food immune reactivity.
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn More
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Acinetobacter, Aspergillus, Babesia + Ehrlichia + Bartonella, Blastocystis hominis, Borrelia burgdorferi, Campylobacter jejuni, Candida albicans, Chlamydias, Citrullinated EBV, Clostridium difficile, Cryptosporidium, CYP450, mimic Hepatitis C Peptide, Cytomegalovirus, Entamoeba histolytica, Giardia lamblia, Helicobacter pylori, Human + Chlamydia HSP-60, Human Herpesvirus-6, Klebsiella, Mycobacterium avium, Mycoplasmas, Penicillium, Porphyromonas gingivalis, Rotavirus, Stachybotrys chartarum, Streptococcal M Protein, Streptococcus mutans, Streptozymes, Yersinia enterocolitica
